thermal degradation study highlights the expressLC™ system’s throughput and selectivity introduction application note
Whether it is degradation studies to challenge the specificity of a
drug substance or drug product assay, analysis of toxicological dosing solutions, or long term stability studies (LTSS)-the number
accelerated thermal degradation
of samples can be overwhelming. For specificity and LTSS
of indomethacin drug product
studies, selectivity is a crucial aspect of analysis: low level
impurities need to be detected before they become regulatory
issues. The high throughput and excellent selectivity of the
ExpressLC systems is expressly designed to address these time
and resource intensive activities. Do you need to re-inject some
samples due to instrumental failure during a long instrumental
run? The ExpressLC system can make several injections with the sample volume required for one conventional LC analysis. No
more embarrassing “insufficient sample for analysis” data entries.
ExpressLC systems transform routine analyses into consistent, high-quality data.
figure 1. chromatogram of thermally-degraded indomethacin
figure 2. experimental conditions and area percent table
Mobile phase: A/B water/acetonitrile with 0.1% TFA Flow rate:
species peak expressLC system specifications
expressLC-100 Single-channel System: Includes binary gradient eksigent technologies
pump, electronic injection valve, column temperature control, and array-
based UV detection system. Optional high-speed autosampler available.
expressLC-800 8-channel Parallel System: Includes 8 binary gradient
pumps, 8 electronic injection valves, 8 column temperature control
compartments, an array-based UV detection system and high-throughput
new jersey office/laboratory flow rate range pump type
Microfluidic direct pumping system with independent flow control
feedback for each mobile phase. Retention time RSD < 0.5%.
High pressure gradient mixing. System can run full gradients as rapidly as 8 seconds. Maximum gradient length 2 hrs. at 5 µL/min.
delay volume mobile phase compatibility
All mobile phases compatible with 316 stainless steel, PEEK, and silica.
Eksigent Variable-Volume Injection System (software selectable).
Standard injection volume 10–250 nL (larger injection volumes available).
columns System optimized for 2.5–15 cm, 300 µm i.d. capillary LC columns
column temperature control Software selectable from 27–40°C; stability within ± 0.1°C
detection UV absorbance detection from 200–380 nm using linear CCD array detector. Detector drift ≤ 4 x 10-4 AU/hr Non-linearity ≤ 5% @ 2 AU.
flow cell 45 nL microfabricated flow cell with integral fiber optics, 4 mm path length
autosampler High-throughput CTC autosampler available
system control Computer with graphical user interface for control of all system parameters. Software allows import of run tables and creates CDF, text, and Excel files for data export and analysis. Tracking of instrument runtime, column usage, total injections, solvent usage, lamp hours, and error codes. System drivers available for Thermo Electron’s Xcalibur and Applied Biosystems/MDS SCIEX Analyst 1.4.1 mass spectrometer software.
report features Generates reports that include method conditions, chromatograms, peak retention times and areas, and spectral absorbance map.
dimensions expressLC-100 System: 21" (53 cm) wide, 20" (51 cm) deep, 18" (46 cm) high expressLC-100 Autosampler: Additional 14" (36 cm) high and 6" (15 cm) wide expressLC-800 System: 30" (76 cm) wide, 34" (86 cm) deep, 40" (102 cm) high expressLC-800 Autosampler: Additional 16" (41 cm) high and 16" (41 cm) wide computer Additional lab space needed for keyboard, mouse and monitor 2005 Eksigent Technologies. All rights reserved. Information subject to change without notice. Eksigent is a registered trademark and ExpressLC is a trademark of Eksigent Technologies. All other trademarks are the property of their respective owners. Printed in the USA. AN-405-X03
Virginia Cooperative Extension PUBLICATION 354-312 Three-prong American ginseng plant. Producing and Marketing Wild Simulated Ginseng in Forest and Agroforestry Systems Introduction other hand, wild ginseng sells for over $300 a pound andthe market demand in Asia for wild roots is practicallyAmerican ginseng ( Panax quinquefolium , Araliaceaefamily) is a familiar plant t
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