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Monoclonal Antibody to TNF-alpha
Purified Antibody (0.025 mg)
Isotype:
Specificity:
The mouse monoclonal antibody MAb1 recognizes human 17-26 kDa cytokineTNF-alpha (tumor necrosis factor alpha).
Regulatory Status:
Immunogen:
Species Reactivity:
Application:
Western BlottingELISAApplication note:Can be used as capture antibody in combination with biotinylatedantibody MAb11.
Functional Applicationneutralization Purification:
Purified from cell culture supernatant by protein-A affinity chromatography.
Concentration:
Storage Buffer:
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 Storage / Stability:
Store at 2-8oC. Do not freeze. Do not use after expiration date stamped on viallabel.
Expiration:
Lot Number:
Background:
TNF-alpha is a cytokine produced by monocytes, macrophages, neutrophils, NKcells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDafree molecule, or as a 26 kDa membrane protein. TNF-alpha easily forms stabletrimers, but also other multimeric complexes. In the immune system, it is animportant regulator, which has cytolytic and cytostatic activity against a range oftumor cells, increases fibroblast proliferation and supports neutrophil chemotaxisand phagocytosis.
For laboratory research only, not for drug, diagnostic or other use.
EXBIO Praha | Nad Safinou II 341 | 252 42 Vestec u Prahy | Czech RepublicTel: +420 261 090 666 | Fax: +420 261 090 660 | [email protected] | www.exbio.cz References:
*Ahlstedt I, Lindholm C, Lönroth H, Hamlet A, Svennerholm AM, Quiding-JärbrinkM: Role of local cytokines in increased gastric expression of the secretorycomponent in Helicobacter pylori infection. Infect Immun. 1999 Sep;67(9):4921-5.
*Lindholm C, Naylor A, Johansson EL, Quiding-Järbrink M: Mucosal vaccinationincreases endothelial expression of mucosal addressin cell adhesion molecule 1 inthe human gastrointestinal tract. Infect Immun. 2004 Feb;72(2):1004-9.
*Wahlström J, Katchar K, Wigzell H, Olerup O, Eklund A, Grunewald J: Analysis ofintracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis. AmJ Respir Crit Care Med. 2001 Jan;163(1):115-21.
*Yan SR, Qing G, Byers DM, Stadnyk AW, Al-Hertani W, Bortolussi R: Role ofMyD88 in diminished tumor necrosis factor alpha production by newbornmononuclear cells in response to lipopolysaccharide. Infect Immun. 2004Mar;72(3):1223-9.
*Visser J, Graffelman W, Blauw B, Haspels I, Lentjes E, de Kloet ER, NagelkerkenL: LPS-induced IL-10 production in whole blood cultures from chronic fatiguesyndrome patients is increased but supersensitive to inhibition by dexamethasone.
J Neuroimmunol. 2001 Oct 1;119(2):343-9.
*Cesaro-Tadic S, Dernick G, Juncker D, Buurman G, Kropshofer H, Michel B,Fattinger C, Delamarche E: High-sensitivity miniaturized immunoassays for tumornecrosis factor alpha using microfluidic systems. Lab Chip. 2004 Dec;4(6):563-9.
For laboratory research only, not for drug, diagnostic or other use.
EXBIO Praha | Nad Safinou II 341 | 252 42 Vestec u Prahy | Czech RepublicTel: +420 261 090 666 | Fax: +420 261 090 660 | [email protected] | www.exbio.cz

Source: http://www.exbio.cz/pdf/data_sheet_new.py/CLO000000000000505/1/18/datasheet-11-687-C025.pdf