Surgical Sperm Retrieval
1 in 6 couples experience difficulty conceiving and might require assistance to achieve their dream of a
family. It is advisable to have tried to conceive for at least 12 months before seeking our help, except if one
of the partners is known to have a condition that is known to delay/prevent conception.
One of these conditions is where the male partner is known to have a problem that prevents him from
consummating the union and/or producing sperm. These problems include: Impotence
Impotence means the inability to achieve erection of the penis and it can occur as an isolated problem in any
relationship or as a symptom of an unhappy relationship. It could occur all the time (total or primary) or only
under certain situations (selective or secondary). Most cases of impotence (9 out of 10) are of the secondary
type. Secondary impotence tends to occur in a specific situation during sex with a particular partner. The
man may be able to achieve erection in other situations including during sleep, on waking up, sexual
fantasising, during masturbation, or with different sexual partners. What causes impotence?
Primary impotence may be due to a lack of male hormones (hypogonadism) or underlying diseases that
cause nerve damage (such as diabetes) or reduced blood flow to the penis. Anaemia, tuberculosis and
cancer may also cause primary impotence. Secondary impotence is largely due to psychological factors.
Other factors that can contribute include tiredness, alcohol and/or drug abuse, and the use of certain
medicines (such as some high blood pressure and anti-psychotic medicines).
'ageing on its own does not cause impotence in men'
Problems of impotence
Problems that arise from impotence include sexual frustration, relationship difficulties and infertility. It can
contribute to a feeling of low self-esteem and inadequacy in the male partner. Treatment of impotence
Impotence is best treated in a clinic with appropriate specialists who have experience of these matters.
Primary impotence will usually respond following treatment of the underlying disease. Psychotherapy and
counselling can help secondary impotence by helping the individual resolve the psychological reasons
behind the impotence. Impotence that occurs in an otherwise good relationship will need examination and
can be helped by some modification of the couple's sexual techniques. The steps of a typical programme of modification involve:
encouraging the couple to practise foreplay and non-penetrative sexual arousal
allowing vaginal penetration (but not thrusting) when the male partner's confidence is restored that he
allowing gentle controlled thrusting interrupted by periods of rest when the penis can be maintained in
the vagina for a few minutes without losing its firmness
The treatment of male impotence has been revolutionised in recent times by the use of medicines such as
Viagra. Viagra works by improving the blood flow pattern of the penis such that it does not only improve the
flow but also helps retain the blood in the penis (a necessity for adequate erection). It is successful for both
primary and secondary impotence, with more than 3 in 4 men treated achieving erection successfully. Use of
Viagra must be supervised as it can cause side effects and may not be suitable for people with certain
diseases (especially of the heart and lungs). Surgery
See surgical sperm retrieval below. Ejaculation problems
Ejaculation is the process whereby semen (sperm) is released from the penis at the time of the male orgasm.
It is brought about by a combination of mental and physical stimulation. These cause rhythmic contractions
of the muscles of the penis that close off the internal opening into the bladder leading to release of semen to
the outside. The two common ejaculation problems are premature and retrograde ejaculation.
- is the achievement of orgasm and release of semen well before the couple wish
this to happen during the act of intercourse. This could be during foreplay before penetration takes place, at or soon after penetration, or in the early stages of intercourse earlier than the couple wish.
- is the passage of released semen (often at the appropriate time) backwards
rather than forward along the urethra to end up in the bladder.
What causes ejaculation problems?
Premature ejaculation can be due to stress, nervousness and tension. Some men may become accustomed
to quick ejaculation because they have been used to hurried masturbation or intercourse due to fear of
discovery. Psychological problems in the relationship may contribute to the problem, for instance if the male
has some fear of the female partner. The male partner may come to fear that he will always ejaculate
prematurely, ensuring he will. Retrograde ejaculation can occur in any situation where the internal end or
sphincter of the urethra (the urine tract in the penis) is damaged. This causes the urethra to lose the ability to
close off at the time of ejaculation. It can be caused by birth defects of the penis, surgery to the urethra
including removal of the prostate gland (prostatectomy), and disorders of the nerves supplying the area as
can occur in multiple sclerosis and diabetes. Problems of premature ejaculation
Problems of premature ejaculation are two folds:
ejaculation is not delayed long enough for the female partner to have adequate sexual fulfilment and
infertility (difficulty with conceiving) if it occurs before penetration
Premature ejaculation can thus cause a great deal of frustration and be a source of sexual and relationship
difficulties, as well as childlessness. Furthermore, if premature ejaculation continues for a prolonged period it
could result in male impotence. Problems of retrograde ejaculation
Retrograde ejaculation may come to light because of a complaint of absence of semen after ejaculation or it
may be picked up during investigations for infertility. The major problem that this causes is infertility because
no semen is deposited in the female vagina. The problem is usually confirmed by showing the presence of
sperm in a urine sample obtained after ejaculation. Treatment of ejaculation problems
Psychosexual counselling has a big role to play in the treatment of premature ejaculation. The affected
couple will be educated on the known facts about the sexual response cycle and guided towards pacing their
sexual activity. We will teach couples how to practice masturbation of the male by the female to a point just
before ejaculation. This will be repeated several times over in sessions to reinforce the art of controlling
ejaculation in the male. Once this is achieved, penetrative sex may be resumed initially with some guidance.
We can recover sperm from urine after an act of sexual intercourse to treat retrograde ejaculation. The
sperm is washed in a special fluid before it is injected into the womb of the female partner (artificial or intra-
uterine insemination) around the time of ovulation. We sometimes combine this with use of fertility drugs to
improve ovulation. Up to 1 in 5 couples treated in this way may be able to achieve a pregnancy. Surgical
sperm retrieval is indicated when these other treatments are unsuccessful. Surgical sperm retrieval (SSR)
We undertake surgical sperm retrieval as a day case procedure to obtain sperm from men unable to produce
sperm for any reason. The sperm is then utilised for assisted conception (IUI or IVF/ICSI). We offer two
forms of surgical sperm retrieval:
Epididymal sperm aspiration (PESA) -
this procedure is used to get sperm from the bag around the
testes of men who ordinarily do not produce sperm by themselves for use in IUI or IVF/ICSI.
Testicular sperm extraction (TESE) -
this procedure is used to get sperm from the testes of men who
ordinarily do not produce sperm by themselves for use in IUI or IVF/ICSI.
Investigation of the couple
We undertake a comprehensive investigation of the male and female to fully understand their fertility needs
before proceeding to surgical sperm retrieval. A detailed interview and examination of both partners is
undertaken. We assess the female's ovarian function with blood tests and ultrasound; determine her tubal
patency by an ultrasound based test called HyCoSy. We assess the male's hormone levels and perform an
ultrasound of the pelvis. We undertake a virology screen for both partners checking for HIV, hepatitis B and
hepatitis C. Counselling
We recommend and provide counselling for couples going through this kind of fertility assessment and
treatment in recognition of the stressful nature of this condition. Please ask us how we can help you with this. How we perform SSR
We perform SSR as a day case procedure as follows:
Epididymal sperm aspiration (PESA) -
under local/general/sedation anaesthesia, we insert a needle into
the bag of sperm around the testis and suck sperm out into the syringe. The sperm is assessed by our embryologist and either used immediately for treatment or frozen in straws for future use.
Testicular sperm extraction (TESE) -
under local/general/sedation anaesthesia, we make a small cut into
and remove a small piece of tissue from the testis. The tissue is processed by our embryologist and sperm extracted from it and either used immediately for treatment or frozen in straws for future use.
What can go wrong?
Like every surgical procedure, SSR carries risks that prospective patients need to be aware of including:
Risks of anaesthesia
- these are thankfully uncommon and relate mostly to unexpected allergic reactions
- there is a small risk of bleeding during and after the procedure but this is fortunately not
severe enough to warrant blood transfusion of to be life threatening.
- the procedure is associated with moderate pain and so we provide painkillers during the early
- this occurs sometimes and can be a cause for concern. It usually reflects tissue
inflammation during the healing process.
- there is a small risk of infection in the testis afterwards; this usually responds well to
of procedure - we do not always succeed in retrieving sperm from the testis and will advice
couples immediately of the success or otherwise of the retrieval attempt.
P.O. Box 265, Sheffield, S3 7XY
Tel. 0208 245 4369 British Infertility Counsellors Association (BICA)
69 Division Street, Sheffield, South Yorkshire
Tel. 01342 843 880 Human Fertilisation and Embryology Authority (HFEA)
30 Artillery Lane, London, E1 7LS
Tel. 0207 377 5077;
Eccezionale soggiorno a Cipro Nord, la nuova stella del Mediterraneo, dall’ 11 al 19 giugno A solo € 570,00 (min. 40 partecipanti) Questo incredibile prezzo è possibile grazie ad un sostanzioso contributo del governo Cipriota, atto a incentivare il turismo nell’Isola Le spiagge ancora libere ed incontaminate, deserte con un mare stupendo, l’acqua limpida e calda, la sabbia bia
SYNTHESIS AND PROPERTIES OF THE NEW ACYCLIC DERIVATIVE OF LUMINAROSINE J. Nowak, J. Milecki, B. Skalski Faculty of Chemistry, A. Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland Pyridinium derivatives of nucleosides are interesting objects of spectral, photophysical and photochemical research . Pyridinium salt derived from 2',3', 5'-tri-O-acetylinosine, when irradi