Microsoft word - deweese cv 13 07 01.docx

Joseph  E.  Deweese,  Ph.D.  
Assistant  Professor  
College  of  Pharmacy  and  Health  Sciences  
Lipscomb  University  
[email protected]  
Office:  615-­‐966-­‐7101  
Professional Interests
Research Interests
Nucleic acid enzymes, DNA topoisomerases, anti-cancer therapeutics, DNA damage and repair
Education
2004-2009 Ph.D., Biochemistry Vanderbilt University School of Medicine, Nashvil e, Tennessee Dissertation Title: The DNA Cleavage Reaction of Human Type II Topoisomerases 2000-2004 B.S., Biochemistry Freed-Hardeman University, Henderson, Tennessee Memberships
American Association for Cancer Research, 2009- American Association of Colleges of Pharmacy, 2009- American Chemical Society, 2009- American Society for Biochemistry and Molecular Biology, 2013- Association of Biochemistry Course Directors, 2010- Tennessee Pharmacists' Association, 2009- PROFESSIONAL APPOINTMENTS:
Academic Experience
Assistant Professor of Pharmaceutical Sciences, Lipscomb University Col ege of Pharmacy
and Health Sciences (2009 - Present).
Adjunct Assistant Professor of Biochemistry, Vanderbilt University School of Medicine (2009
- Present). Research position in col aboration with Dr. Neil Osheroff.
Research Fellow, Osheroff Laboratory, Department of Biochemistry, Vanderbilt University School
of Medicine (February, 2009 - May, 2009). Post-doctoral researcher.
Adjunct Instructor of Biology, Lipscomb University Department of Biology (2007 -
2008). Course Instructor for BY 1003, Fundamentals of Biology, 2 semesters.
Other Academic Experience:
Graduate Research Assistant in Biochemistry, Osheroff Laboratory, Department of
Biochemistry, Vanderbilt University School of Medicine (2005 - 2009).
Laboratory training of graduate students, Osheroff Laboratory, Department of Biochemistry,
Vanderbilt University School of Medicine (2007 - 2009).
Fal 2007 - Alyssa Johnson, Interdisciplinary Graduate Program, VUSM
Spring 2008 - Adam C. Ketron, Interdisciplinary Graduate Program, VUSM.

Tutor for Molecular Foundations of Medicine, Vanderbilt University School of Medicine (2007 -
2009). First year course for medical students related to molecular biology and biochemistry.
Supervisor for undergraduate research student, Osheroff Laboratory, Department of
Biochemistry, Vanderbilt University School of Medicine (2008). Amber M. Burch, Lipscomb
University, Biology Department.
Laboratory Assistant for Organic Chemistry and Biochemistry, Department of Chemistry and
Engineering Sciences (2002 - 2004). Laboratory coordinator under the supervision of Dr. Jerry
Thornthwaite.
Undergraduate Research Assistant and Research Coordinator, Cancer Research Institute of
West Tennessee (2002 - 2004). Perform and oversee laboratory research and assist with Organic
Chemistry and Biochemistry labs.
Undergraduate Research Assistant and Laboratory Assistant, Department of Chemistry
and Engineering Sciences, Freed-Hardeman University (2001 - 2002). Perform laboratory
research in flow cytometry and assist with Organic Chemistry labs.
TEACHING:
Courses Taught
2009-present – Lipscomb University College of Pharmacy:
PHSC 1213 Biomolecular Chemistry (course coordinator, lecturer)
PHSC 1512 Integrated Biomedical Sciences Lab I (course coordinator, lab instructor)
PHSC 1522 Integrated Biomedical Sciences Lab II (course coordinator, lab instructor)
PHAD 1111 Applied Christian Values in Pharmacy (co-course coordinator, lecturer)
PHAD 2111 Applied Christian Caring and Compassion (co-course coordinator, lecturer)
PHAD 3111 Applied Christian Ethics in Pharmacy (co-course coordinator, lecturer)
PHSC 2633 Pharmacologic Basis of Therapeutics III (lecturer)
PHSC 3912 Introduction to Research (course coordinator, mentor)
2007, 2008 – Lipscomb University, Department of Biology:
BY 1003 Fundamentals of Biology (course coordinator and lecturer)
Teaching-Other
Student Advising
2012-2013 – Advisor/mentor for 13 student pharmacists
2011-2012 – Advisor/mentor for 13 student pharmacists
2010-2011 – Advisor/mentor for 13 student pharmacists
2009-2010 – Advisor/mentor for 12 student pharmacists
Supervising Student Research
2013 – Lipscomb University Col ege of Pharmacy Summer Research Program
Research mentor for Elizabeth G. Gibson (P3)
Project: Characterization of human topoisomerase II mutants
Research mentor for Kel ie Regal (Senior)
Project: Characterization of agents that act on topoisomerase II
2013 – Research Mentor during fal and spring semesters:
Research mentor for Elizabeth G. Gibson (P2)
Project: Characterization of human topoisomerase II mutants
Research mentor for Kel ie Regal (Junior)
Project: Characterization of agents that act on topoisomerase II
2012 – Lipscomb University Col ege of Pharmacy Summer Research Program
Research mentor for Elizabeth G. Gibson (P2)
Project: Characterization of human topoisomerase II mutants Research mentor for Kel ie Regal (Junior) Project: Characterization of agents that act on topoisomerase II 2011 – Research mentor for Elizabeth G. Gibson (P1) and Lisa M. Yinger (P2) during fall and spring semesters Project: Purification and characterization of human topoisomerase II mutants 2011 – Lipscomb University Col ege of Pharmacy Summer Research Program Mentored David A. Jacob (P3) and Lisa M. Yinger (P2) DAJ Project: Etoposide catechol synthesis and characterization LMY Project: Establishing protocol for the production of purified topoisomerase II 2010 - Lipscomb University Col ege of Pharmacy Summer Research Program Mentored Andrew Jacob (P2) Project: The Quinone Metabolite of Etoposide acts as a Topoisomerase II Poison
INTELLECTUAL CONTRIBUTIONS:
Refereed Articles
1. Lee, S., Jung, S., Heo, K., Byl, J. W., Deweese, J. E. , Neil Osheroff, Sungchul Hohng, (2012). DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proceedings of the National Academy of the Sciences, 109(8), 2925-2930. 2. Jacob, D. A., Mercer, S. L., Osheroff, N., & Deweese, J. E. (2011). Etoposide is a Redox- Dependent Topoisomerase II Poison. Biochemistry, 50(25), 5660-5667. 3. Schmidt, B. H., Burgin, A. B., Deweese, J. E., Osheroff, N., & Berger, J. M. (2010). A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature, 465 (7298), 641-644. 4. Deweese, J. E. & Osheroff, N. (2010). The Use of Divalent Metal Ions by Type II Topoisomerases. Metal omics, 2 (7), 450-459. 5. Deweese, J. E. & Osheroff, N. (2009). Coordinating the two protomer active sites of human topoisomerase IIalpha: Nicks as topoisomerase II poisons. Biochemistry, 48 (7), 1439-1441. 6. Deweese, J. E., Osheroff, M. A., & Osheroff, N. (2009). DNA topology and topoisomerases: teaching a 'knotty' subject. Biochemistry and Molecular Biology Education, 37 (1), 2-10. 7. Deweese, J. E., Guengerich, F. P., Burgin, A. B., & Osheroff, N. (2009). Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry, 48 (38), 8940-8947. 8. Deweese, J. E., Burch, A. M., Burgin, A. B., & Osheroff, N. (2009). Use of divalent metal ions in the DNA cleavage reaction of human type II topoisomerases. Biochemistry, 48 (9), 1862-1869. 9. Deweese, J. E., Burgin, A. B., & Osheroff, N. (2008). Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage. Nucleic Acids Research, 36 (15), 4883-4893. 10. Deweese, J. E. & Osheroff, N. (2008). The DNA cleavage reaction of topoisomerase II: Wolf in sheep's clothing. Nucleic Acids Research, 37 (3), 738-748. 11. Deweese, J. E., Burgin, A. B., & Osheroff, N. (2008). Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry, 47, 4129-4140. Manuscripts In Preparation
1. Jacob, D. A., Gibson, E. G., Mercer, S. L., and Deweese, J. E. Etoposide catechol is an oxidizable topoisomerase II poison. Under review. 2. Gibson, E. G. and Deweese, J. E. Covalent Poisons of Topoisomerase II. Under review.
Refereed Proceedings
Abstracts and Poster Presentations:
1. Gibson, E. G., Straughn, L. Y., & Deweese, J. E. (2013). Generation of Topoisomerase IIα Mutants with Altered Etoposide Sensitivity. American Association of Colleges of Pharmacy (AACP) Annual Meeting. 2. Regal, K. M., Mercer, S. L., & Deweese, J. E. (2013). Characterization of HU-331 as a Cannabinoid Quinone Inhibitor of Topoisomerase II. American Association of Colleges of Pharmacy (AACP) Annual Meeting. 3. Deweese, J. E., Jacob, D. A., Gibson, E. G., & Mercer, S. L. (2013). Etoposide Catechol is an Oxidizable Topoisomerase II Poison. FASEB Experimental Biology 2013. 4. Gibson, E. G., Jacob, D. A., Mercer, S. L., & Deweese, J. E. (2012). Etoposide Metabolites as Topoisomerase II Poisons. American Association of Colleges of Pharmacy (AACP) Annual Meeting. 5. Deweese, J. E. (2012). A team-based "enzyme workshop" for teaching enzyme function and pharmacologic targeting to first-year pharmacy students. American Association of Colleges of Pharmacy (AACP) Annual Meeting. 6. Fowler, M., Mercer, S. L., Phipps, S., Deweese, J. E. , McCormack, J., Holli Dilks, Scott Akers, (2011). Development of an Integrated Biomedical and Pharmaceutical Sciences Teaching Laboratory. American Association of Colleges of Pharmacy (AACP) Annual Meeting. 7. Deweese, J. E. & Osheroff, N. (2009). Nicks as poisons of topoisomerase II: Coordinating the two protomer subunits of topoisomerase IIalpha. American Association for Cancer Research Annual Meeting. 8. Deweese, J. E. & Osheroff, N. (2008). Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of topoisomerase II. American Association for Cancer Research Annual Meeting. 9. Deweese, J. E. & Osheroff, N. (2008). The DNA cleavage reaction of topoisomerase 10. Deweese, J. E., Burgin, A. B., & Osheroff, N. (2008). The DNA cleavage reaction of topoisomerase IIalpha. Southeastern Regional American Chemical Society Meeting. 11. Deweese, J. E., Burch, A. M., & Osheroff, N. (2008). A two-metal-ion mechanism for DNA cleavage by human topoisomerase IIalpha and beta. Southeastern Regional American Chemical Society Meeting. 12. Deweese, J. E. & Osheroff, N. (2007). Isolating topoisomerase II-mediated DNA cleavage using 3'-bridging phosphorothiolates. American Association for Cancer Research Annual Meeting. 13. Brooks, W. S., Deweese, J. E., & Thornthwaite, J. (2002). Characterization of tumor tissues by analysis of DNA content. Tennessee Academy of Sciences Undergraduate Research Forum. Non-Refereed Proceedings
Abstracts and Poster Presentations:
1. Gibson, E. G., Straughn, L. Y., and Deweese, J. E. (2013). Generation of Topoisomerase IIα Mutants with Altered Etoposide Sensitivity. Lipscomb University Student Scholar Symposium. 2. Regal, K. M., Mercer, S. L., and Deweese J. E. (2013). Characterization of HU-331 as a Cannabinoid Quionone Inhibitor of Topoisomerase II. Lipscomb University Student Scholar Symposium. 3. Gibson, E. G. and Deweese, J. E. (2012). Generation and Characterization of Topoisomerase IIα Mutants. Lipscomb University Col ege of Pharmacy Summer Research Program and Vanderbilt Summer Science Academy. 4. Regal, K. M., Mercer, S. L., and Deweese J. E. (2012). Characterization of the Novel Cannabinoid Quionone HU-331. Lipscomb University Col ege of Pharmacy Summer Research Program and Vanderbilt Summer Science Academy. 5. Gibson, E. G. and Deweese, J. E. (2012). Generation and Characterization of Etoposide- Resistant Mutants of Topoisomerase II. Lipscomb University Student Scholar Symposium. 6. Jacob, D. A., Deweese, J. E., & Mercer, S. L. (2011). Synthesis and Biological Evaluation of Etoposide E-Ring Analogs. Lipscomb University Col ege of Pharmacy Summer Research Program and Vanderbilt Summer Science Academy. 7. Yinger, L. M. & Deweese, J. E. (2011). Purification and Characterization of His-Tagged Topoisomerase IIα. Lipscomb University Col ege of Pharmacy Summer Research Program and Vanderbilt Summer Science Academy. 8. Deweese, J. E., Schmidt, B., Burgin, A., Berger, J., & Osheroff, N. (2010). The DNA Cleavage Reaction of Type II Topoisomerases. Symposium on Frontiers of Biophysics, Seoul Nation University, Seoul, Korea: . (Invited) 9. Jacob, A., Mercer, S. L., Osheroff, N., & Deweese, J. E. (2010). The Quinone Metabolite of Etoposide Acts as a Redox-Dependent Topoisomerase II Poison. Lipscomb University Col ege of Pharmacy Summer Research Program and Vanderbilt Summer Science Academy. 10. Burch, A. M., Deweese, J. E., & Osheroff, N. (2008). A Two Metal Ion Mechanism for DNA Cleavage by Human Topoisomerase IIbeta. Vanderbilt Summer Science Academy. 11. Deweese, J. E. & Thornthwaite, J. (2004). Stabilization of ATP after release from K562 cel s using luciferin/luciferase assays. Alpha Chi National College Honor Society Regional Meeting. Presentation of Papers
Akers, W. S., Deweese, J. E. , Fowler, M. W. , & Mercer, S. L. (2012). Back to the Basics: Integrating Curricular Content in the Pharmaceutical Sciences Through Laboratory Based Exercises. American Association of Colleges of Pharmacy (AACP) Annual Meeting, Orlando, Florida. Deweese, J. E. (2012). Reconciling the Evidence: Design and Decay? Christian Scholars Conference, Nashvil e, Tennessee. Grants Funded
2012: DEWEESE, J. E., Loving Service as Sacred Work: A Transformational Curriculum for the Healthcare Professional ($20,885.00), Baptist Healing Trust 2011: DEWEESE, J. E., Faculty Summer Grant ($8,000.00) SERVICE:
Service to the University
College Assignments
Chair:
2011-2012: College of Pharmacy, Pharmacy Integrity Council

Member:
2013-2014: Lipscomb University Academic Technology Task Force
2012-2013: College of Pharmacy Self-Study Committee 2012-2013: College of Pharmacy Academic Progressions Committee 2009-2013: College of Pharmacy Admissions Committee 2009-2012: College of Pharmacy, Pharmacy Integrity Council 2011-2012: Environmental Health and Safety Committee 2010-2011: iTeach Initiative: iPad User Group: User group finding academic applications for iPads and other technologies. 2010-2011: College of Pharmacy Meharry Ad Hoc Committee 2009-2010: Scholarship and Awards Committee Service to the Profession
Reviewer - Article / Manuscript
2012: Chemical Research in Toxicology.
2009, 2013: Journal of Medicinal Chemistry.
Reviewer - Book / Textbook
2011: Remington: The Science and Practice of Pharmacy, chapter reviewer
Other Professional Service Activities
2010: Lipscomb Col ege of Pharmacy - Pharmacy Research Day, Planned and Organized the first
Pharmacy Research Day for the Department of Pharmaceutical Sciences in the College of
Pharmacy, Nashvil e, Tennessee.
Invited Presentations
2013: Freed-Hardeman University, Alumni Day Chapel Presentation.
2012: American Association of Colleges of Pharmacy (AACP) Annual Meeting.
2012: Lipscomb CSI Academy.
2012: Lipscomb/Tri-Star HCA Health Care Academy.
2012: Christian Scholars Conference, Nashvil e, Tennessee.
2011: Lipscomb University College of Pharmacy, Enzyme Purification and Characterization
presentation for the Pharmaceutical Sciences Seminar Series.
2011: Freed-Hardeman University, Applied Christian Values in Pharmacy: a course on values and
ethics for health professionals presented to pre-professional students.
2009: Freed-Hardeman University Research Day, Research presentation, The DNA Cleavage
Reaction of Type II Topoisomerases, Henderson, Tennessee.
2009: Vanderbilt University Medical Center, Department of Biochemistry Retreat Presentation,
Cutting Up: Topoisomerase II-Mediated DNA Cleavage, Nashvil e, Tennessee.
2007: Lipscomb University, Cel ular and Molecular Biology, guest lecturer, DNA Topoisomerases.
2006: Freed-Hardeman University Research Day, Research presentation, Topoisomerases: How
Your Cel s Relax and Unwind, Henderson, Tennessee.
Service to the Community
Member of a Committee
2010 – 2013: Fighting Duchenne Foundation, Member of the Board of Directors for the Fighting
Duchenne Foundation for Duchenne Muscular Dystrophy
Other Community Service Activities
2011 – 2013: Coordinator for Bible Bowl teams, Walnut Street Church of Christ, Dickson, TN 2009 – 2013: Volunteer Organizer Habitat for Humanity, Dickson, TN, coordination of volunteers for Habitat for Humanity builds 2007: Biochemistry Student Association, Department of Biochemistry, VUSM, President Speech / Presentation at a Community Meeting
2010 – 2011: Scientist in the Classroom - Honors Biology II, Creek Wood High School, Assisted an
Honors Biology II class in learning about enzymes and reactions.
2010: Scientist in the Classroom - Honors Biology II, Creek Wood High School, Assisted an
Honors Biology II class in learning about enzymes and reactions.
2005-2013: Walnut Street Church of Christ Col ege Class, Teaching Summer Col ege Class
Faculty Development
Research-Related Conference/Seminar
2013: Experimental Biology 2013, FASEB Annual Meeting. Boston, MA.
2011: American Association for Cancer Research Annual Meeting. Cancer Research Conference. Orlando,
Florida.
2010: Lipscomb Col ege of Pharmacy - Pharmacy Research Day. Organized first pharmacy research day for
the department and col ege. Nashvil e, Tennessee.
2010: American Chemical Society Webinar. 'From a Beaker to a Bottle: Overview of the Drug Discovery and
Development Process for Smal Molecule Therapeutics', Ann Newman, Ph.D., May 6, 2010. Web-based,
Virtual.
2010: American Chemical Society Webinar. 'Green Chemistry: Innovation and Application for the New
Decade', Anne Wal in, Dow Chemical, May 20, 2010. Web-based, Virtual.
2009: American Association for Cancer Research Annual Meeting. Denver, Colorado.
2008: American Association for Cancer Research Annual Meeting. San Diego, California.
2008: Southeastern Regional American Chemical Society Meeting. Nashvil e, Tennessee.
2007: American Association for Cancer Research Annual Meeting. Los Angeles, California.
2004: Vanderbilt University Medical Center. Responsible Conduct in Research Training Conference.
Nashvil e, Tennessee.
Instructional-Related Conference
2012: American Association of Colleges of Pharmacy (AACP) Annual Meeting. Attended meeting, presented
posters and session presentation. Orlando, Florida.
2011: American Association of Colleges of Pharmacy (AACP) Annual Meeting. Attended AACP Annual
Meeting and assisted in presenting a poster. San Antonio, Texas.
2010: Vanderbilt Summer Science Academy Mentorship Workshop. Mentorship workshop by Dr. Kathy
Friedman of Vanderbilt University, Department of Biological Sciences. Nashville, Tennessee.
2010: American Association of Colleges of Pharmacy (AACP) Annual Meeting. Attended Annual AACP
conference and seminars. Seattle, Washington.
2010: Vanderbilt University School of Medicine Thomas A. Hazinski Faculty Development Workshop.
Instructional training workshop for Vanderbilt faculty. Nashvil e, Tennessee.
2009: American Association of Colleges of Pharmacy (AACP) Annual Meeting. Boston, Massachusetts.
2009: Vanderbilt University Center for Teaching Series. Course Design for Student Learning. Nashvil e,
Tennessee.
2009: Vanderbilt University Center for Teaching Series. Learner-Centered Teaching Strategies. Nashvil e,
Tennessee.
2009: Vanderbilt University School of Medicine Thomas A. Hazinski Faculty Development Workshop. Instructional Training Workshop for Vanderbilt Faculty. Nashvil e, Tennessee. 2008: Vanderbilt Summer Science Academy Mentorship Workshop. Mentorship workshop by Dr. Kathy Friedman of Vanderbilt University, Department of Biological Sciences. Nashvil e, Tennessee. Other Professional Development
2013: Building Cultural Bridges in the Workplace, LUCOP Faculty Development
2012: Weight of the Nation Series, LUCOP Faculty Development Fall Series
2009: Identifying Learning Disabilities in the Classroom. Seminar by Dr. Monte Betz of Lipscomb University
College of Education on identifying learning disabilities in the classroom. Nashvil e, Tennessee.
2004: Alpha Chi National College Honor Society Regional Meeting. Nashvil e, Tennessee.
Professional Seminars / Workshops
2010: American Chemical Society Webinar. 'Success Factors for a Consulting Practice in Chemistry', Wil iam
Golton, Ph.D., April 29, 2010. Web-based, Virtual.
2009: Turning Point Technologies Basic and Advanced Training. Training in use of Turning Point software
and devices to incorporate active learning into the classroom. Nashvil e, Tennessee.
2009: PCAT 101: Interpretation of PCAT Scores, Pearson Webinar. Webinar on the interpretation of PCAT
scores by Pearson. Nashvil e, Tennessee.
Technology-Related Training
2013: SAS statistical software package training, Lipscomb University
2012: Apple iPad Technology in Education. Training on using the iPad in the classroom. Nashville,
Tennessee.
2010: Lipscomb University iTeach Program. Selected to participate in Lipscomb University's iTeach program
exploring uses of the iPad in teaching and learning. Nashvil e, Tennessee.
2010: Made for Learning: Apple in Higher Education Seminar. Training by Apple specialists in using Apple
technology in teaching. Nashvil e, Tennessee.
2009: SEDONA Training. Training in the functions and use of Sedona software. Nashvil e, Tennessee.
Honors & Awards
2009: Graduate Student Travel Grant Vanderbilt University Graduate School. 2008: Graduate Student Travel Grant Vanderbilt University Graduate School. 2005: National Research Service Award Traineeship (pre-doctoral), Multidisciplinary Basic Research Training in Cancer (T32 CA05952), 2005-2007 National Institutes of Health. 2004: Faculty Scholarship-Leadership Award Freed-Hardeman University. 2004: Outstanding Chemistry Graduate Award, Department of Chemistry and Engineering Sciences, FHU. 2003: Hibbett-Trul Health Arts Scholarship Freed-Hardeman University. 2002: Dean's Academic Scholarship Freed-Hardeman University. 2002: Research Award West Region Tennessee Academy of Sciences Col egiate Meeting.

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