Beijing Solarbio Science & Technology Co., Ltd.
D8040 Dexamethasone 地塞米松 DEXAMETHASONE CRYSTALLINE CAS NUMBER: 50-02-2 SYNONYMS: 9 -Fluoro-16 -Methylprednisolone, Desamethasone PHYSICAL PROPERTIES:
Appearance: White to white with a yellow cast powder
Melting Point = 255℃ with decomposition1
Dexamethasone is a synthetic glucocorticoid.
STABILITY / STORAGE AS SUPPLIED:
This product should be stored at 2-8℃ and protected from light. If properly stored, it will
SOLUBILITY / SOLUTION STABILITY:
Dexamethasone is practically insoluble in water. It is soluble in ethanol, methanol, acetone,
dioxane and slightly soluble in chloroform.4 Solarbio routinely tests the solubility at 50
mg/mL in ethanol with heat yielding a clear, colorless to faint yellow solution. However,
dexamethasone will precipitate out of solution as the temperature returns to room
temperature. At 25 mg/mL in methanol5 or ethanol6 clear, colorless solution is obtained
without heating.Dexamethasone solutions are stable for at least 30 days when stored at
4℃ and protected from light. The solution may be aliquoted and stored at -20℃. However,
insufficient information is available to assess the shelf-life of the frozen solution.5
Beijing Solarbio Science & Technology Co., Ltd.
Dexamethasone has a biological half-life in plasma of about 2-5 hours.6
APPLICATIONS:
Dexamethasone is a potent and highly stable glucocorticoid. It exhibits general properties
of corticosteroids and is used for its anti-inflammatory and anti-rheumatic activity and
immunosuppressant effects in a wide variety of disorders.4In biochemical studies,
dexamethasone has been used to induce liver tyrosine aminotransferase.2 It has also been
employed as an antiemetic drug in controlling nausea and vomiting induced by
chemotherapy.Although the mechanism is not fully understood, it is believed that the
glucocorticoid may inhibit prostaglandin synthesis.7 It has also been reported that
dexamethasone inhibits the pyrogenic activity of prostaglandin F2a but not that of
prostaglandin E2. The dosage used was in the range of 0.5 mg/kg injected subcutaneously
into rats in a volume of 1 ml/kg.8 Dexamethasone has also shown to inhibit the release of
phospholipase A2, a potent pro-inflammatory enzyme, in stimulated macrophages of sheep
A working range of 4-500 ng/mL is recommended as a medium supplement for cell culture
REFERENCES:
1. British Pharmacopoeia, vol. I, 178 (1988).
2. Data for Biochemical Research, 3rd ed., 205 (1986).
3. Merck Index, 11th ed., 464, #2922 (1989).
4. Martindale: The Extra Pharmacopoeia, 30th ed., 728 (1993).
6. Clarke’s Isolation and Identification of Drugs, 2nd ed., 518 (1986).
7. Markman, M. et al., New Engl. J. Med., 311, 549-552 (1984).
8. Coelho, M.M. et al., Eur. J. Pharmacol., 238, 391-394 (1993).
9. Vadas, P., Life Sciences, 30, 155-162 (1982).
I - RAPPEL 1) Définition Il s’agit d’une ectoparasitose due à un acarien, Sarcoptes scabiei hominis qui vit dans l’épiderme humain, à l’origine d’une dermatose très prurigineuse et contagieuse. C’est une maladie endémo-épidémique très fréquente et cosmopolite. 2) Réservoir et vecteur Le réservoir exclusif est l’homme malade. La principale source est c
ALTANA AG Am Pilgerrain 15 61352 Bad Homburg v.d.H. T +49 (0) 6172 1712-160 F +49 (0) 6172 1712-158 ALTANA: Strong profit growth in the first half year Profit before taxes (EBT) rises 25%; operating growth margin 28% Bad Homburg, August 4, 2003 - ALTANA AG (NYSE: AAA; FSE: ALT), Bad Homburg, reported sales of approximately €1.4 billion for the first half of 2003, up 7% on the
Beijing Solarbio Science & Technology Co., Ltd.
D8040 Dexamethasone 地塞米松 DEXAMETHASONE CRYSTALLINE 
Beijing Solarbio Science & Technology Co., Ltd.
Dexamethasone has a biological half-life in plasma of about 2-5 hours.6
APPLICATIONS: