CURRICULUM VITAE Birth Date: Citizenship: Current Position:
Chief Professor, Department of Anatomy (Division of Cell biology),
School of Medicine, Iwate Medical University (Morioka, Japan)
Education:
Doctor of Medicine, Asahikawa Medical College
Bachelor of Medicine, Iwate Medical University
Employment:
Chief Professor, Department of Anatomy (Division of Cell biology),
School of Medicine, Iwate Medical University (Morioka, Japan)
Adjunctive Associate Professor, Department of Cellular Metabolism, National Institute of Physiology (Okazaki, Japan)
Associate Professor, Department of Anatomy 1, Asahikawa Medical College (Asahikawa, Japan)
Assistant, Department of Anatomy 1, Asahikawa Medical College (Asahikawa, Japan)
Assistant, Department of Anatomy 2, School of Medicine, Iwate Medical University (Morioka, Japan)
Adjunct Appointments:
Adjunctive Associate Professor, Department of Cellular Metabolism, National Institute of Physiology (Okazaki, Japan)
Visiting Lecturer, Department of Anatomy 3, Niigata University (Niigata, Japan)
Visiting Lecturer, Department of Anatomy, Akita University (Akita, Japan)
Special teaching lectures (selected) Technical Seminar (Japan Society of Histochemistry and Cytochemistry)
2000 Ca2+ imaging 2004 Confocal microscopy 2009 Living tissue imaging
Technical Seminar (Japanese Society of Microscopy)
2001 Ca2+ imaging 2002 Confoclmicroscopy 2005 Pitfalls of fluorescence imaging
Professional Activities:
Assessment in lNEDO (New Energy and Industrial Technology Development Organization)
Assessment in Grants-in-Aid for Scientific Research, JSPS (Japan Society for the Promotion of Science)
Society Memberships:
Japan Society of Histochemistry and Cytochemistry
2006 Award of Journal of Electron Microscopy
Current Primary Research Interests:
Visualization of cell signaling in living tissues
Cell cycle and intracellular calsium dynamics
Paneth cells and defense system in gastrointestinal tract
Functional morphology of exocrine secretions of glands
Internal committee activity in Iwate Medical University
Councilor of educational foundation of Iwate Medical University
Committee on Medical Education (Chief administrator)
Committee on Center of Liberal Arts and Siences (Chief Administrator)
Committee on Promoting of Medical Research Project
Committee on High-tech Research Center of Iwate Medical University (General managr, 2001-2008)
Publications (Selected)
1. Satoh Y, Nitatori T: On the fine structure of lymph hearts in amphibia and reptiles. Satoh Y,
Nitatori T. In: Hearts and Heart-like organs. Vol. 1. ed. by Bourne GH Academic Press (1980)
2. Satoh Y, Nitatori T: Ultrastructure of the corpuscular nerve ending in the lymph heart of
the turtle (Pseudemys scripta elegans). Arch Histol Jpn 46:115-124 (1983)
3. Satoh Y: Ultrastructure of Paneth cells in germ-free rats, with special reference to the
secretory granules and lysosomes. Arch Histol Jpn 47:293-301 (1984)
4. Satoh Y, Nagashima Y, Oomori Y, Ishikawa K, Matoba M, Ono K: Scanning electron
microscopical observation on the isolated mucosa of rat small intestine: with special reference to the intestinal crypts. Anat Anz 159:305-309 (1985)
5. Satoh Y, Vollrath L: Quantitative electron microscopic observations on Paneth cells of
germfree and ex-germfree Wistar rats. Anat Embryol 173:317-322 (1986)
6. Satoh Y, Ishikawa K, Ono K, Vollrath L: Quantitative light microscopic observations on
Paneth cells of germ-free and ex-germ-free Wistar rats. Digestion 34:115-121 (1986)
7. Satoh Y, Ishikawa K, Tanaka H, Ono K: Immunohistochemical observations of
immunoglobulin A in the Paneth cells of germ-free and formerly-germ-free rats. Histochemistry 85:197-201 (1986)
8. Satoh Y: Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in
germ-free mice. Cell Tissue Res 251:87-93 (1988)
9. Satoh Y, Vollrath L: Lack of "synaptic" ribbons in the pineal gland of BALB/c mice. J
10. Satoh Y, Ishikawa K, Tanaka H, Oomori Y, Ono K: Immunohistochemical observations of
lysozyme in the Paneth cells of specific-pathogen-free and germ-free mice. Acta Histochem 83:185-188 (1988)
11. Satoh Y: Atropine inhibits the degranulation of Paneth cells in ex-germ-free mice. Cell
12. Satoh Y, Oomori Y, Ishikawa K, Satoh T, Ono K: Application of immunohistochemistry to
the isolated mucosa of the mouse gastrointestinal tract, with special reference to somatostatin cells. Acta Anat 133:229-233 (1988)
13. Satoh Y, Ishikawa K, Oomori Y, Yamano M, Ono K: Effects of cholecystokinin and
carbamylcholine on Paneth cell secretion in mice: a comparison with pancreatic acinar cells. Anat Rec 225:124-132 (1989)
14. Satoh Y, Yamano M, Matsuda M, Ono K: Ultrastructure of Paneth cells in the intestine of
various mammals. J Electron Microsc Tech 16:69-80 (1990)
15. Satoh Y, Saino T, Ono K: Effect of carbamylcholine on Harderian gland morphology in
rats. Cell Tissue Res 261:451-459 (1990)
16. Satoh Y, Ishikawa K, Oomori Y, Takeda S, Ono K: Secretion mode of the Harderian gland
of rats after stimulation by cholinergic secretagogues. Acta Anat 143:7-13(1992)
17. Satoh Y, Ishikawa K, Oomori Y, Takeda S, Ono K: Bethanechol and a G-protein activator,
NaF/AlCl3, induce secretory response in Paneth cells of mouse intestine. Cell Tissue Res 269:213-220 (1992)
18. Matsuda M, Satoh Y, Ono K: Scanning electron microscopic and light microscopic
observations on morphological changes of freeze-dried bone implantation in rats: comparison with fresh autogenous bone transplantation. Histol Histopath 7:393-403 (1992)
19. Satoh Y, Habara Y, Kanno T, Ono K: Carbamylcholine-induced morphological changes
and spatial dynamics of [Ca2+]c in Harderian glands of guinea pigs: calcium-dependent lipid secretion and contraction of myoepithelial cells. Cell Tissue Res 274:1-14 (1993)
20. Satoh Y, Oomori Y, Ishikawa K, Ono K: Configuration of myoepithelial cells in various
exocrine glands of guinea pigs. Anat Embryol 189:227-236 (1994)
21. Iuchi H, Satoh Y, Ono K: Postnatal development of neuropeptide Y- and calcitonin
gene-related peptide-immunoreactive nerves in the rat urinary bladder. Anat Embryol 189:361-373 (1994)
22. Satoh Y, Ono K, Moutairou K: Paneth cells of African giant rats (Cricetomys gambianus).
23. Satoh Y, Habara Y, Ono K, Kanno T: Carbamylcholine-and catecholamine-induced
intracellular calcium dynamics of epithelial cells in mouse ileal crypts. Gastroenterology 108:1345-1356 (1995)
24. Gesase AP, Satoh Y, Ono K: G-protein activation enhances Ca2+ -dependent lipid secretion
of the rat Harderian gland. Anat Embryol 192: 319-328 (1995)
25. Satoh Y, Gesase AP, Habara Y, Ono K, Kanno T: Lipid secretory mechanisms in the
mammalian Harderian gland. Mirrosc. Res. Tech. 34: 104-110 (1996)
26. Gesase AP, Satoh Y, Ono K: Secretagogue-induced apocrine secretion in the Harderian
gland of rat. Cell Tissue Res. 285: 501-507 (1996)
27. Satoh Y, Sano K, Habara Y, Kanno T: Effects of carbachol and catecholamines on
ultrastructure and intracellular calcium-ion dynamics of acinar and myoepitjelial cells of lacrimal glands. Cell Tissue Res. 289: 473-485 (1997)
28. Satoh Y, Kumagai K, Satou H, Orii M: Intracellular calcium dynamics of secretory cells of
the intestine. in "Dynamic Cells" Eds by S Yagihashi, T. Kachi and M. Wakui, Elsevier, pp. 125-131 (1998)
29. Satoh Y, Nishimura T, Kimura K, Mori S, Saino T: Application of real-time confocal
microscopy for observation of living cells in tissue specimens. Human Cell 11(4): 191-197 (1998)
30. Kimura K, Yamashita H, Nishimura T, Mori S, Satoh Y: Application of real-time confocal
microscopy to observations of ATP-induced Ca2+-oscillatory fluctuations in intact corneal epithelial cells. Acta Histochem Cytochem. 32 (1): 59-63 (1999)
31. Kimura K, Nishimura T, Satoh Y: Effects of ATP and its analogues on [Ca2+]i dynamics in
the rabbit corneal epithelium. Arch. Histol. Cytol. 62(2): 129-138 (1999)
32. Satoh Y, Williams M, Habara Y: Effects of AlF4- and ATP on intracellular calcium
dynamics of crypt epithelial cells in mouse small intestine. Cell Tissue Res. 298: 295-305 (1999)
33. Mori S, Saino T, Satoh Y: Effect of low temperatures on compound 48/80-induced
intracellular Ca2+ changes and exocytosis of rat peritoneal mast cells. Arch. Histol. Cytol. 63(3): 261-270 (2000)
34. Gesase AP, Satoh Y: Sexual diffences and effects of castration on secretory mode and
intracellular calcium ion dynamics of golden hamster Harderian gland. Cell Tissue Res. 304: 81-90 (2001)
35. Warashina A, Satoh Y: Modes of secretagogue-induced [Ca2+]i responses in individual
chromaffin cells of the perfused rat adrenal medulla. Cell calcium 30(6): 395-401 (2001)
36. Saino T, Matsuura M, Satoh Y: Application of real-time confocal microscopy to
intracellular calcium ion dynamics in rat arterioles. Histochem. Cell Biol. 117:295- 305 (2002)
37. Saino, T., Matsuura, M. and Satoh, Y. : Comparison of the effect of ATP on intracellular
calcium ion dynamics between rat testicular and cerebral arteriole smooth muscle cells. Cell Calcium 32:155-165 (2002)
38. Kubo-Watanabe, S., Satoh, Y., and Saino, T.: ATP-induced [Ca2+]i changes through
gap-junctional communication in the corneal epithelium. Jap. J. Ophthalmol. 46(5):479-87 (2002)
39. Kubo-Watanabe S, Goto S, Saino T, Tazawa Y, Satoh Y : ATP-induced [Ca2+]i changes in
the human corneal epithelium. Arch Histol Cytol, 66: 63-72 (2003)
40. Gesase A, Satoh Y : Apocrine secretory mechanism: recent findings and unresolved
problems. Histol Histopathol, 18: 597-608 (2003)
41. Matsuura M, Saino T, Satoh Y : Response to ATP is accompanied by Ca2+ influx via P2X
purinoceptors in the coronary arterioles of golden hamsters. Arch Histol Cytol 67: 95-105 (2004)
42. Saino T, Satoh Y : Application of real-time confocal laser scanning microscopy to observe
living cells in tissue specimens. J Electron Microsc 33: 49-56 (2004)
43. Kuroda T, Satoh Y, Akutsu-Yamauchi H, Shikanai Y, Miyata S, Saino T, Russa D, Habara
Y, Cui Z.,-J: Quantitative analysis of photodamage during fluorescent bioimaging: monitoring of nitric oxide production using DAF-2. Bioimages 14:9-18 (2006)
44. Misaki T, Satoh Y, Saino T, Ogawa A: The role of protease activated receptors on
intracellular calcium ion dynamics of vascular smooth muscles with special reference to cerebral arterioles. Arch Histol Cytol 69:49-60 (2006)
45. Misaki T, Satoh Y, Saino T, Kuroda T, Masu K, Russa D, Ogawa K: Immunohistochemical
localization of protease-activated receptors in cerebral and testicular arterioles of rats: dependence on arteriole size and organ-specificity. Arch Histol Cytol 71/3,179-184 (2008)
46. Saino T, Misaki T, Matsuura M, Shikanai T, Satoh Y： Dipyridamole inhibits intracellular
calcium transients in isolated rat arteriole smooth muscle cells. Arch Histol Cytol 71: 235-247 (2008)
47. Russa AD, Ishikita N, Masu K, Akutsu H, Saino T, Satoh Y: Microtubule remodeling
mediates the inhibition of store-operated calcium entry during mitosis in COS-7 cells. Arch Histol Cytol 71:249-263 (2008)
Army Malaria Institute – its Evolution Third Decade (1st Half): 1985-1990 Karl H. Rieckmann, Anthony W. Sweeney, Michael D. Edstein, Robert D. Cooper, Stephen P. Frances AbstractThe first half of the third decade (1985-1990) after the establishment of the Malaria Research Unit was characterised by a substantial increase in laboratory and field activities. Various new procedures were developed
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