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• International Classification of Vestibular
• Internal (self) or external (surround)
• Feeling of postural instability (e.g., swaying or
• Disturbed sense of spatial orientation
Bisdorff, et al., J Vest Research, 2009
1871 Westphal - Die Agoraphobie (fear of squares)
Patients find it impossible to cross open squares and walk along certain
– Legrande du Saulle - concept of ‘fear of fear’
streets. Fear restricts their mobility, [but] they insist that they are not aware of any reasons for their anxiety. It seems to arise as an alien force as soon as a square is crossed or approached. With the anxiety,
– Lannois and Tournier - agoraphobia occurs in
as part of one process, occurs the thought of not being able to cross
individuals with pre-existing psychic anxiety, and is
and a perception of an enormous expanse of space.
elicited by otologic diseases causing vertigo
Kuch and Swinson, Can J Psychiatry, 1992Balaban and Jacob, J Anxiety Disord, 2001
– Dizziness or subjective imbalance with normal exam
– Fluctuating unsteadiness or illusory body perturbations
– Provocative stimuli - bridge, street, crowds
– Accompanied by anxiety and autonomic arousal
– Obsessive-compulsive personality, mild depression
– Onset after periods of stress, medical illness, or vestibular disorder
– A neurologic syndrome, NOT panic or agoraphobia
– Uneasiness about balance or spatial orientation
– Feelings of swaying or rocking when still
– Heightened awareness of normal movement
– Environments with inexact or potentially conflicting visual and
somatosensory cues (bridges, open spaces)
– Dizziness in environments with complex visual stimuli
Jacob, et al., J Psychopath Behav Assess, 1993; Am J Psychiatry, 1996; Bronstein, JNNP, 1995; J Neurol, 2004Anxiety, Depression, and Dizziness in 132 Patients
• Slower on a high versus low platform
• Walk on a walkway • Gait slowest on high narrow walkway
• Stride shortest on high narrow walkway
• Greater sway for subjects with high anxiety
(eyes open). No differences (eyes closed).
• Shorter response latencies, more postural
corrections for subjects with high anxiety.
• Subjects with anxious traits were more
strongly affected by erroneous visual stimuli.
Adkin, et al., 2002; Brown, et al., 2002; Ohno, et al., 2004; Staab and Ruckenstein, Laryngoscope, 2003Carpenter, et al., 2004; Viaud-Delmon, et al., 2000Vestibular Neuronitis and Anxiety in 75 Patients
• Prospective study of physical outcomes
– lightheadedness, heavy headedness, “swimming”
• Hypersensitivity to motion stimuli (SMD)
– Movement of objects in the environment
• A 21st century integrated clinical syndrome
Godemann, et al., J Psychiatric Res, 2005Staab and Ruckenstein. Arch Oto-HNS, 2005, 2007
• Normal physical exam and head imaging
– Exam may provoke symptoms, but not signs of vestibular
• e.g., dizziness, not nystagmus
• Non-specific vestibular test findings
– Isolated peripheral abnormalities are common
• Peripheral deficits ≠ constant dizziness
Staab and Ruckenstein. Arch Oto-HNS, 2005, 2007
• Vestibular laboratory (basic reflex tests)
• A test of integrated balance function
• Misinterpretations of this test continue to be
Cevette, et al., Otolaryn Head Neck Surg, 1995Allum, et al., Gait Posture, 2001; Jacob, et al., Psychosom Med, 1997; JNNP, 2009; Huweler, et al., Behav Res Ther, 2009; Endo, et al., Spine, 2008Ödman & Maire, Acta Oto-Laryngol, 2008
Ereção sem hora marcada é a nova meta dos fármacos São José do Rio Preto, 3 de agosto de 2007 Cecília Dionizio Nova dosagem do medicamento comercializado como Cialis, do laboratório Eli Lilly, chega às farmácias da Europa este semestre, com a proposta de atender a demanda de mais de 50% dos homens, entre 40 e 70 anos, que têm preocupação em manter ou atingir uma ereção. S