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AN EXCUTIVE SUMMARY
MAJOR RESEARCH PROJECT
{F.No. 34-338/2008 (SR)}
ENTITLED

“Preparation, Characterization and Antibacterial Screening of
Some Organometallic Compounds and Complexes”

SUBMITTED BY
DR. BALGOBIND THAKUR
ASSOCIATE PROFESSOR,
DEPARTMENT OF CHEMISTRY,
C.M.SC. COLLEGE, DARBHANGA,
BIHAR-846004.
In our project, drugs Amoxicillin, Ciprofloxacin, Cloxacillin, Isoniazid and
Ofloxacin were taken for study. These have been used here as ligands with Iron
(III), Praseodymium (III), Neodymium (III), Nickel (II), Copper (II) and Zinc (II)
metal ions.
Complexes were formed by usual complex formation methods.
All metal-complexes except that of zinc-complex were coloured. Magnetic
susceptibilities and electrical conductance values were measured and that showed
all metal complexes to be non-electrolytic except that of Ln (III)-ciprofloxacin
metal complexes. Solubility of all the metal complexes and their melting points too
has been determined.
From the elemental analysis and molecular mass determination we could get
molecular formulae of the compounds. From spectral analysis like infrared and
proton nuclear magnetic resonance, we could be in position to identify the ligation
sites in the drug ligand. It was observed that one β-lactam antibiotic amoxicillin
was behaving as tridentate ligand while another β-lactam antibiotic cloxacillin
behaves as bidentate only. Amoxicillin has donor sites amino group, imino group and ketonic group of β-lacatm ring. Cloxacillin has donor sites imino group and the ketonic group of β-lactam skeleton. Antibiotics of quinolones group namely ciprofloxacin and ofloxacin are carboxylate and ketonic group of quinolone ring. Isoniazid metal complexes showed only bidentate ligation through its ketonic group and the amino group. Antibacterial behavior of the metal complexes against Escherichia coli, Mycobacterium tuberculosis, Salmonella typhae and P. Pneumoniae were studied using disc diffusion methods in collaboration with Dr. Arvind Kumar (M.D.) of Kumar Clinic, Darbhanga (Bihar). The complexs of Fe (II), Zn (II), Pr (III) and Nd (III) complexes with amoxicillin are more effective towards bacterium Escherichia coli. The complex of Cu (II) with amoxicillin is approxinately similar efective while complex of Ni (II) is less effective towards bacterium Escherichia coli with respect to the standard drug amoxicillin. The complexs of Fe (II), Cu (II) Zn (II), Pr (III) and Nd (III) complexes with amoxicillin are more effective against bacterium Salmonella typhi. The complex of Ni (II) has no effect on bacterium Salmonella typhi with respect to the standard drug amoxicillin. The complexs of Fe (II), Zn (II), Pr (III) and Nd (III) complexes with amoxicillin are more effective against bacterium P. pneumoniae. The complex of Cu (II) and Ni (II) with amoxicillin is approximately similar efective against bacterium P. pneumoniae with respect to the standard drug amoxicillin. The complexs of Fe (II), Ni (II), Cu (II) and Zn (II), complexes with ciprofloxacin are more effective towards bacterium Escherichia coli. The complexs of Fe (II), Cu (II) and Zn (II), complexes with ciprofloxacin are more effective towards bacterium E. coli and P. pneumoniae. The complex of Ni (II) is not effective towards Salmonella typhi while it is similar effective as the standard drug against P. pneumoniae. The complexes of Pr (III) and Nd (III) with ciprofloxacin is approxinately moderately efective against bacterium Escherichia coli, Salmonella typhi and P. pneumoniae with respect to the standard drug ciprofloxacin. The complexs of Fe (II), Zn (II), Pr (III) and Nd (III) complexes with cloxacillin are more effective towards bacterium Escherichia coli. The complex of Cu (II) with cloxacillin is approxinately similar efective while complex of Ni (II) is less effective towards bacterium Escherichia coli with respect to the standard drug cloxacillin. The complexs of Fe (II), Zn (II), Pr (III) and Nd (III) complexes with cloxacillin are more effective towards bacterium Salmonella typhi and P. pneumoniae. The complex of Ni (II) and Cu (II) has similar effect on towards bacterium Salmonella typhi and P. pneumoniae with respect to the standard drug cloxacillin. All the complexs of Fe (II), Ni (II), Cu (II), Zn (II), Pr (III) and Nd (III) with isoniazid are almost similar effective towards bacterium Mycobacterium tuberculosis in comparison to the standard drug Isoniazid. The complexs of Fe (II), Ni (II), Cu (II) and Zn (II), complexes with ciprofloxacin are more effective towards bacterium Escherichia coli. The complexs of Fe (II), Cu (II) and Zn (II), complexes with ciprofloxacin are more effective towards bacterium Escherichia coli and P. pneumoniae. the complex of Ni (II) is almost similar effective towards Salmonella typhi and P. pneumoniae. The complexes of Pr (III) and Nd (III) with ciprofloxacin is approxinately moderately effective bacterium Escherichia coli, Salmonella typhi and P. pneumoniae with respect to the standard drug ciprofloxacin.

Source: http://www.cmsciencecollegedarbhanga.org/staff/final-report.pdf