Microsoft word - 08 minocycline, tetracycline and doxycycline.doc
Drug Information Sheet - minocycline, tetracycline and doxycycline
Questionnaire for minocycline, tetracycline and doxycycline
1. Are you on any of the following medications?
A. Mineral supplements, e.g., calcium, zinc or iron Yes No B. Antacids
C. Didanosine (Videx®) (HIV medication) Yes No D. Digoxin (heart medication) Yes No E. Isotretinoin (Accutane®, Amnesteem®) (for acne)
F. Lithium (for mental illness) Yes No G. Coumadin® (blood thinner) Yes No H. Birth control pills Yes No
4. Are you planning to become pregnant? Yes No
5. Do you have a history of headaches? Yes No
6. Do you have a history of kidney disease? Yes No DK*
7. Do you have a history of low blood counts? Yes No DK*
8. Do you have a history of liver disease? Yes No DK*
9. Do you have a history of lupus erythematosus? Yes No DK*
10. Do you have a history of excessive sensitivity to sun? Yes No *DK = Don’t know
Bolognia, Jorizzo, Rapini – Dermatology 2/e
Drug Information Sheet - minocycline, tetracycline and doxycycline
Patient information sheet-potential side effects of tetracycline, minocycline and doxycycline
Common:
1. Upset stomach 2. Yellow-gray-brown discoloration of the teeth in unborn children and
children less than 8 years of age; do not use these medications during pregnancy.
3. Vaginal yeast infections. Over-the-counter creams and suppositories such
as Monistat®, Mycelex® and Gyne-Lotrimin® are available.
4. Sensitivity to the sun (especially with doxycycline)
Less Common:
1. Headaches 2. Development of a rash or hives 3. Dizziness (vertigo) with high doses (in particular minocycline); this
4. Blue-gray color within scars (minocycline) 5. Blue or gray spots, especially on the legs (minocycline)
1. Decreased blood counts 2. Severe headaches 3. Inflammation of the liver (minocycline > tetracycline or doxycycline) and
4. Lupus-like syndrome (minocycline) (doxycycline exacerbates systemic
5. Darkening of sun-exposed skin (minocycline) 6. Blistering skin reactions, sometimes severe 7. Severe allergic reactions
Bolognia, Jorizzo, Rapini – Dermatology 2/e
Drug Information Sheet - minocycline, tetracycline and doxycycline
Physician checklist for minocycline, tetracycline and doxycycline
A. decreases tetracycline absorption B. decreases tetracycline absorption C. give tetracyclines one hour before or 4 hours after buffered didanosine:
combination may decrease tetracycline absorption
D. combination may increase digoxin levels E. combination may increase risk of pseudotumor cerebri F. tetracycline and doxycycline may increase lithium levels G. increased anticoagulation H. possible decreased efficacy of birth control pill, but not clearly established
For patients with renal insufficiency, doxycycline is the tetracycline that can be used safely without risk of accumulation and toxicity.
Bolognia, Jorizzo, Rapini – Dermatology 2/e
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