Microsoft word - syllabus for entrance test to phd programme in pharmacy for 2013.doc

Syllabus for entrance test to Ph.D. programme in Pharmacy for 2013
1. PHARMACOLOGY: Pathophysiology of common diseases,basic principles of cell Injury and
adaptations, causes of cellular injury, pathogenesis, morphology of cell injury, adaptations and cell death, basic mechanisms involved in the process of inflammation and repair, vascular and cellular events of acute inflammation, chemical mediators of inflammation, pathogenesis of chronic inflammation, brief outline of the process of repair. 2. IMMUNOPATHOPHYSIOLOGY:T and B cells, MHC proteins, antigen presenting cells, immune
tolerance, pathogenesis of hypersensitivity reactions, autoimmune diseases, AIDS, amyloidosis. 3. PATHOPHYSIOLOGY OF COMMON DISEASES:Asthma, diabetes, rheumatoid arthritis, gout,
ulcerative colitis, neoplasia, psychosis, depression, mania, epilepsy, acute and chronic renal failure, hypertension, angina, congestive heart failure, atherosclerosis, myocardial infarction, congestive heart failure, peptic ulcer, anemias, hepatic disorders, tuberculosis, urinary tract infections and sexually transmitted diseases. Wherever applicable the molecular basis should be discussed. 4. FUNDAMENTALS OF GENERAL PHARMACOLOGY:Dosage forms and routes of administration,
mechanism of action, combined effect of drugs, factors modifying drug action, tolerance and dependence,pharmacogenetics,principles of basic and clinical pharmacokinetics, absorption, distribution, metabolism and excretion of drugs, adverse drug reactions,bioassay of drugs and biological standardization,discovery and development of new drugs, bioavailability and bioequivalence studies. 5. PHARMACOLOGY OF PERIPHERAL NERVOUS SYSTEM:Neurohumoral transmission (autonomic
and somatic), parasympathomimetics, parasympatholytics, sympathomimetics, adrenergic receptor and neuron blocking agents, ganglion stimulants and blocking agents, neuromuscular blocking agents, local anestheticagents. 6. PHARMACOLOGY OF CENTRAL NERVOUS SYSTEM:Neurohumoral transmission in the C.N.S.,
general anesthetics, alcohols and disulfiram, sedatives, hypnotics, anti-anxiety agents and centrally acting muscle relaxants, psychopharmacological agents (anti-psychotics), anti-maniacs and hallucinogens, antidepressants, anti-epileptics drugs, anti-parkinsonian drugs, analgesics, antipyretics, narcotic analgesics and antagonists, C.N.S. stimulants, drug addiction and drug abuse. 7. PHARMACOLOGY OF CARDIOVASCULAR SYSTEM:Drugs used in the management of
congestive cardiac failure, antihypertensive drugs, anti-anginal and vasodilator drugs, including calcium channel blockers and beta adrenergic antagonists, anti-arrhythmic drugs, anti-hyperlipedemic drugs, drugs used in the therapy of shock. 8. DRUGS ACTING ON THE HEMOPOIETIC SYSTEM:Hematinics, anticoagulants, Vitamin K and
hemostatic agents, fibrinolytic and anti-platelet drugs, blood and plasma volume expanders. 9. DRUGS ACTING ON URINARY SYSTEM:Fluid and electrolyte balance, diuretics.
10. AUTACOIDS:Histamine, antihistaminic drugs, 5-HT- its agonists and antagonists, prostaglandins,
thromboxanes and leukotrienes, angiotensin, Bradykinin and substance P and other vasoactive peptides, non-steroidal anti-inflammatory and anti-gout agents. 11. DRUGS ACTING ON THE RESPIRATORY SYSTEM:Anti-asthmatic drugs including bronchodilators,
anti-tussives and expectorants, respiratory stimulants. 12. DRUGS ACTING ON THE GASTROINTESTINAL TRACT:Antacids, anti-secretory and anti-ulcer
drugs, laxatives and anti-diarrhoeal drugs, appetite stimulants and suppressants, ermetics and anti-emetics, Miscellaneous: carminatives, demulcents, protectives, adsorbents, astringents, digestants, enzymes and mucolytics. 13. PHARMACOLOGY OF ENDOCRINE SYSTEM:Hypothalamic and pituitary hormones, thyroid
hormones and anti thyroid drugs, parathormone, calcitonin and Vitamin D, insulin, glucagons, incretins, oral hypoglycemic agents and insulin analogs, ACTH and corticosteroids, androgens and anabolic steroids, estrogens, progesterone and oral contraceptives, drugs acting on the uterus. 14. CHEMOTHERAPY:General principles of chemotherapy, bacterial resistance, sulfonamides and
cotrimoxazole, antibiotics- Penicillins, Cephalosporins, Aminoglycosides, Chloramphenicol, Macrolides, Tetracyclines, Quinolones, fluoroquinolones and miscellaneous antibiotics,chemotherapy of tuberculosis, leprosy, fungal diseases, viral diseases, HIV and AIDS, urinary tract infections and sexually transmitted diseases, malaria, amoebiasis and other protozoal infections and anthelmentics,chemotherapy of malignancy and immunosuppressive agents. 15. PRINCIPLES OF TOXICOLOGY:Definition of poison, general principles of treatment of poisoning
with particular reference to barbiturates, opioids, organophosphorous and atropine poisoning, heavy metals and heavy metal antagonists. 16. BASIC CONCEPTS OF PHARMACOTHERAPY:Clinical Pharmacokinetics and individualization of
drug therapy, drug delivery systems and their biopharmaceutic&therapeutic considerations, drugs used during infancy and in the elderly persons (Pediatrics& Geriatrics), drugs used during pregnancy, drug induced diseases, the basics of drug interactions, general principles of clinical toxicology, common clinical laboratory tests and their interpretation. 17. IMPORTANT DISORDERS OF ORGANS, SYSTEMS AND THEIR MANAGEMENT:Cardio-vascular
disorders- Hypertension, congestive heart failure, angina, acute myocardial infarction, cardiac arrhythmias. 18. CNS DISORDERS:Epilepsy, parkinsonism, schizophrenia.
19. DEPRESSION RESPIRATORY DISEASE:Asthma.
20. GASTROINTESTINAL DISORDERS:Peptic ulcer, ulcerative colitis, hepatitis, cirrhosis.
21. ENDOCRINE DISORDERS:Diabetes mellitus and thyroid disorders.
22. INFECTIOUS DISEASES:Tuberculosis, urinary tract infections, enteric infections, upper respiratory
infections, Hematopoietic Disorders- Anemia. 23. JOINT AND CONNECTIVE TISSUE DISORDERS:Rheumatic diseases, gout and hyperuricemia.
24. NEOPLASTIC DISEASES:Acute Leukaemia, Hodgkin's disease, therapeutic drug monitoring,
concept of essential drugs and rational drug use. 25. BIOPHARMACEUTICS & PHARMACOKINETCS:Passage of drugs across biological barrier
(passive diffusion, active transport, facilitated diffusion, ion-pair formation and pinocytosis),factors influencing absorption- biological, physico-chemical, physiological and pharmaceutical,drug distribution in the body, plasma protein binding.Significance of plasma drug concentration measurement. Compartment model- Definition and Scope. Pharmacokinetics of drug absorption - Zero order and first order absorption rate constant using Wagner-Nelson and residual methods. Volume of distribution and distribution coefficient. Compartment kinetics- One compartment and two compartment models. Determination of pharmacokinetic parameters from plasma and urine data after drug administration by intravascular and oral route. Clearance concept, mechanism of renal clearance, clearance ratio, determination of renal clearance. Extraction ratio, hepatic clearance, biliary excretion, extra-hepatic circulation. Non-linear pharmacokinetics with special reference to one compartment model after I.V. drug administration. 26. CLINICAL PHARMACOKINETICS:Definition and scope,dosage adjustment in patients with and
without renal and hepatic failure,design of single dose bio-equivalence study and relevant statistics,pharmacokinetic drug interactions and their significance in combination therapy. 27. BIOAVAILABILITY AND BIOEQUIVALENCE:Measures of bioavailability, Cmax, tmax, Keli and
Area Under the Curve (AUC),design of single dose bioequivalence study and relevant statistics,review of regulatory requirements for conducting bioequivalent studies. Biopharmaceutical Classification System (BCS) of drugs. 28. IMMUNOLOGY AND IMMUNOLOGICAL PREPARATIONS:Principles, antigens and heptans,
immune system, cellular/humoral immunity, immunological tolerance, antigen-antibody reactions and their applications. Hypersensitivity, active and passive immunization. Vaccines and sera: their preparation, standardization and storage. 29. GENETIC RECOMBINATION:Transformation, conjugation, transduction, protoplast fusion and gene
cloning and their applications. Development of hybridoma for monoclonal antibodies. Study of drugs produced by biotechnology such as Activase, Humulin, Humatrope, HB etc. 30. ANTIBIOTICS:Historical development of antibiotics. Antimicrobial spectrum and methods used for
their standardization. Screening of soil for organisms producing antibiotics, fermenter, its design, control of different parameters. Isolation of mutants, factors influencing rate of mutation. Design of fermentation process. Isolation of fermentation products with special reference to penicillins, streptomycinstetracyclines and vitamin B12. Address: Opp University Bus Stand, University Road, Navrangpura, Ahmedabad–380009 Gujarat,INDIA
Phone: +91-79-26302414-18 FAX: +91-79-26302419 E-mail: [email protected]

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