Why Does Framing Influence Judgment?
A few years ago, British women were informed that the use
Second, there is strong empirical evidence that condi-
of the contraceptive pill leads to a 2-fold increase in the
tional probabilities (such as sensitivity and specificity) tend
risk of thromboembolism. Many stopped taking the pill,
to confuse minds, specifically when one wants to infer the
which resulted in unwanted pregnancies and abortions.
chances of having a disease after a positive test. The reason
If the official statement had instead been that the pill
for the confusion again lies in the reference classes, which
increases the risk from 1 to 2 in 14,000 women, few women
in this case are switched: the sensitivity refers to patients
would have been scared. Life and death can depend on how
with disease, and specificity to patients without disease.
This second form of confusion can be avoided by using
Yet framing itself is not the problem—every piece of
information communicated requires a form or frame. The
Third, relative risk reduction (RRR) tends to mislead
problem is a larger, societal one: the lack of education in
patients into overestimating the benefits of therapies and
understanding uncertainties and risks, also known as
consequently increases their willingness to consent (un-
innumeracy. For instance, Sheridan et al. in this issue of
informed consent), compared to absolute risk reduction
the Journal of General Internal Medicine report that only
(AAR) and number needed to treat (NNT). Again, the reason
2% of patients could correctly answer three simple numer-
has to do with the reference class. For instance, many
acy questions, and that nonwhites, females, and patients
health organizations inform women that “mammography
without college education misunderstood treatment
screening reduces the risk of dying from breast cancer by
benefits most.1 Our schools do not teach children the
25%” (RRR). But 25% of what? A woman may assume that
mathematics that will be most useful in their future lives:
the percentage refers to women like herself who consider
statistical thinking. Statistical thinking and the art of
screening, and erroneously conclude that 25 of every 100
framing are also absent from most medical curricula and
women who participate in screening are saved. In contrast,
from continuing education offered to physicians. This
when one frames the benefit as “screening reduces the risk
omission is costly and irresponsible.
of dying from 4 to 3 in 1,000 women” (an ARR of 1 in 1,000),
We could easily help patients, medical students, and
physicians, turning their collective innumeracy into insight.
Thus, instead of these three frames that tend to confuse
Programs now exist that can achieve this goal with simple
patients and physicians—conditional probabilities, single-
tools and in short time.2 The know-how is based on two
event probabilities, and RRR—we can teach physicians
sources: on empirical studies that show when framing has
to use frames that foster insight: frequency statements,
an effect, as in the excellent review by Moxey et al.3 (this
natural frequencies, and absolute risks.2,4 Good hypotheses
volume), and, equally important, on theoretical knowledge
about why framing influences minds can assist in planning
of why framing has an effect. Here are a few examples of
new studies and ordering the apparent chaos of positive
First, the use of single-event probabilities tends to
In contrast, Sheridan et al.1 report that RRR led to
confuse patients. Consider the case of a physician who
more correct answers by patients than did NNT and ARR.
used to inform his clients of Prozac’s side effects by saying,
This surprising result may well be due to their unusual
“If you take Prozac, you have a 30% chance of a sexual
phrasing of ARR (“treatment A reduces the chance that
problem.” When the physician changed his way of commu-
you will develop disease Y by 10 per 1,000 persons”), which
nicating the risk by using the frequency statement “out of
is a hybrid between a single-person and a frequency
every 10 patients to whom I prescribe Prozac, 3 to 5 expe-
statement, and their equally awkward phrasing of NNT. I
rience a sexual problem,” his patients were less anxious and
wager that a clearer statement of ARR and NNT will
more willing to take Prozac. It turned out that many of
increase the understanding of the size of benefit (e.g., ARR:
them had originally understood that “something would go
“participating in treatment A prevents 10 out of every 1,000
awry in 30% of my sexual encounters.” For single-event
persons from getting disease Y”; NNT: “100 patients need
versus frequency statements, the mechanism of framing is
to undergo treatment A in order to prevent 1 from getting
clear. A single-event probability, by definition, does not
disease Y”). Transparent wording is the essence of a frame
specify the reference class (30% of what?). The physician
thought of his patients, but his patients thought of their
Finally, there are positive frames (“you have an 80%
own sexual encounters. The confusion can be avoided by
chance of surviving surgery”) versus negative frames (“you
consistently using frequency statements.
have a 20% chance of dying from surgery”). My hypothesis
is that they have an effect if patients can reasonably
REFERENCES
assume that the physician’s choice of frame conveys addi-tional information, such as dynamic information. For
1. Sheridan SL, Pignone MP, Lewis CL. A randomized comparison of
instance, the positive frame can imply that surgery will
patients’ understanding of number needed to treat and other
increase the survival chance from 0% to 80%, whereas the
common risk reduction formats. J Gen Intern Med. 2003;18:884–892.
negative frame suggests that surgery increases the chance
2. Gigerenzer G. Calculated Risks: How to Know When Numbers
Deceive You. New York: Simon & Schuster, 2002 (UK edition: Reck-
Understanding when and why framing has an effect
oning with Risk: Learning to Live with Uncertainty. London: Penguin
is essential for informed consent and shared decision mak-
ing. It is high time to enter this knowledge into the curricula
3. Moxey A, O’Connell D, McGettigan P, Henry D. Describing treatment
effects to patients: how they are expressed makes a difference. J Gen
of medical schools.— Gerd Gigerenzer, MD,Center for Adaptive Behavior and Cognition, Max Planck Institute for
4. Hoffrage U, Lindsey S, Hertwig R, Gigerenzer G. Communicating
Human Development, Berlin, Germany.
statistical information. Science. 2000;290:2261–2.
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International Journal of Ozone Therapy 7: 000-000, 2008 Is Medical Ozone Safe when Injected Intra-articularly? A Comparative Histological Study in Rat E. ILIAKIS*, I. PETROPOULOS**, A. ILIAKI***, E. AGAPITOS****, G. AGROGIANNIS**** * Orthopaedic Surgeon Hospital Inspector N.M.Y. Athens; Greece** Orthopaedic Surgeon National Centre for Emergency Aid; Greece*** School of Veterinary Medicine, A