9. Supervisor of completed PhD-studies and Postdoctoral works
10. Organisation of Symposia and Workshops
11. Publications 11.1 Publications (peer-reviewed)
Switzerland E-mail: [email protected] Phone: +41 61 321 13 15 Cellular: +76 549 75 15
1. Personal information
Date of Birth: 27.02.1971 Place of Birth: Ravensburg/Germany Nationality: German Marital status: Civil partnership, one daughter 2. Education
2002-2010
Habilitation in Pharmaceutical Technology, University of Basel, Switzerland.
2007 Manuscript accepted by the Faculty of Natural Sciences, University of
Basel. Topic: New Concepts in Powder Technology and Solid Dosage Form Design (Faculty responsibility: Prof. Dr. Beat Ernst).
Topic: Generics – exactly the same or different? (Generika – genau dasselbe oder doch anders?) (Faculty responsibility: Prof. Dr. Matthias Hamburger). Awarded the title “Privatdozentin” by the Faculty of Natural Sciences, University of Basel.
Ph.D-thesis in Pharmaceutical Technology, University of Basel,
Topic: Investigation of transdermal heparin permeation from various
liposomal formulations throught the skin (Faculty responsibility: Prof. Dr.
1995-1996
Practical training in the frame of the Pharmacy studies at Novartis, Wehr and Apotheke Stadtmitte, Stuttgart, Germany.
1990-1995
Pharmacy studies at Albert-Ludwig-University in Freiburg/Breisgau, Germany.
Abitur at Matthias Erzberger Gymnasium in Biberach/Riss, Germany.
3. Professional career
since 2011
Editorial Board Member of International Journal of Pharmaceutics.
University Lecturer (Privatdozentin) in Pharmaceutical Sciences, University of Basel.
Group leader Industrial Pharmacy at the Department of Pharmaceutical Sciences, University of Basel. The research group was established as a turning platform between academia and pharmaceutical industry working in the area of formulation science, industrial and physical pharmacy, and process technology. Responsibility for a group of about 10 scientists, internationally comprised of Postdoctoral fellows, PhD-students, visiting scientists, and master students.
Member of the Senate (Regenz), University of Basel as representative of the faculty of natural sciences (group II).
Member of the Executive Board of the Department of Pharmaceutical Sciences, University of Basel.
Responsibility for the practical training in Pharmaceutical Technology, University of Basel ad interim with the following main task:
Organisation and accomplishment of the three practical courses in the areas liquid-sterile dosage forms, disperse dosage forms, and solid dosage forms. In all three courses, development studies were performed from the active pharmaceutical ingredient to the final dosage form and documented in a protocol. Number of students: 80 per annum.
Certificate in Entrepreneurship, The William F. Glavin Center for Global Management, Babson College, Massachusetts, USA.
Consultant for the law firm Greenberg Traurig, New York in patent conflicts between pharmaceutical companies based in Europe and USA.
Teaching position at the Department of Pharmaceutical Sciences, University of Basel, Switzerland. Since then various contributions in the following areas:
Bachelor level
-Lecture: Pharmaceutical Technology, Liquid-sterile dosage forms: Physico-chemical basics, development concepts, sterile production, and case studies.
-Seminar: Pharmaceutical Technology, about recent topics, such as magnetic drug targeting, floating drug delivery systems etc.
-Lecture: Introduction to Pharmaceutical Sciences: Basics about pharmaceutical dosage forms.
Master level
-Lecture: Proteinformulations for invasive and non-invasive applications: Basics in production of therapeutic proteins, aggregation analytics, reading and discussion of recent scientific publications in the area.
-Lecture: Advanced Pharmaceutical Technology: Focus Industrial Pharmacy: Aspects of Scale-up and process control in granulation and tableting, reading and discussion of scientific publications in the area.
-Supervision of master students (>40).
PhD level
-Kolloquium: Industrial Pharmacy, in collaboration with industry.
-Kolloquium: Compression and Compaction Physics of Pharmaceutical Particulate Material.
-Supervision of 12 completed and 4 running PhD-theses.
Tutor in Bioethics held for pharmacy and biology students at University of Basel.
Participation in the “Dozierendenprogramm” of the University of Basel, Certificate “Hochschuldidaktik”.
Course instructor in presentation skills and body language for pharmacy students.
Assistant of practical courses in the frame of Pharmaceutical Technology education held in liquid sterile dosage forms and liposomal preparations.
Locum pharmacist at Apotheke Stadtmitte, Stuttgart, Germany.
In parallel to the professional career, continuous education in Pharma-Business, Pharma- Marketing, GMP, Pharmaceutical Development and Production, Scientific Writing, and Rhetoric was performed. 4. Languages
German
5. Computer skills
Very good knowledge of Word, PowerPoint, Excel, and Photoshop. Good knowledge and hand-on experience in Design of Experiments (Quality by Design). 6. Hobbies
Walking and hiking in the nature, travelling, reading, cooking for friends, and dancing. 7. Awards
NETS (New Entrepreneurs in Technology and Science) Award 2004 and NETS Special Award 2004 sponsored by Gebert Rüf Stiftung Basel, Switzerland. SHARE (Swiss House of Advanced Research) Award, Boston, MA, 2004, Selection as the most promising venture idea by the audience in the frame of NETS. FIP Award 2008 presented by Industrial Pharmacy Section for excellent organisation of the workshop "Modern solid dosage form process design and development using chemometric, PAT, and simulation approaches". 8. Supervisor of current research works
Simulataneous determination of metoprolole tartrate and hydrochlothiazide in powder mixtures and tablets using near infrared spectroscopy, PhD-student Branko Vranci, Sponsor: BÜCHI Labortechnik AG, Flawil. FBRM (Focused Beam Reflectance Measurement) as innovative tool in pharmaceutical fluid bed granulation process control, PhD-student Firas Alshihabi, Sponsor: Syrian Ministry of Higher Education. Compressibility and compactibility of powder formulations – investigation from a physico-mathematical perspective with introduction of near infrared spectroscopy, PhD- student Nikos Gentis, Sponsor: Swiss National Science Foundation (SNF). Low dose drug quantification in powder blends by near infrared spectroscopy, PhD- student Lizbeth Martinez, Sponsor: Novartis Pharma AG, Basel. 9. Supervisor of completed PhD-studies and Postdoctoral works
Bausch U.J., 2008. Impact of filling processes on protein solutions, PhD Thesis, University of Basel (Sponsor Roche, Basel). Balzano V., 2008. Soft compaction of MUPS, PhD Thesis, University of Basel (Sponsor MEPHA, Switzerland). Sehic S., 2008. Investigation of variability of primary materials on the intrinsic dissolution behavior of carbamazepine, PhD Thesis, University of Basel (Sponsor
Bosnalijek, Sarajevo). Hadzovic E., 2008. Roller Compaction of Theophylline, PhD Thesis, University of Basel (Sponsor Bosnalijek, Sarajevo). Pasic M., 2008. Study to design stable lansoprazole pellets, PhD Thesis, University of Basel (Sponsor Bosnalijek, Sarajevo). Müller F.S., 2008. Design of fast disintegrating tablets, PhD Thesis, University of Basel (Sponsor Senglet Foundation and SNF). Rumman M., 2009. Understanding the functionality of MCC Rapid as an excipient for DC – Moving towards Quality by Design, PhD Thesis, University of Basel (Sponsor MEPHA Switzerland). Saeed M., 2010. Pharmaceutical tablets and near-infrared spectral information – Investigation of sampled tablet sections and press effect on predictions, PhD Thesis, University of Basel (Sponsor BÜCHI Labortechnik, Flawil). Darronqui E., 2010. Study of the effect of batch size and liquid addition speed on the granulation process using power consumption method as monitoring tool. PhD Thesis, University of Basel (Sponsor CAPES, Brazil). Vejnovic I., 2010. Systematic investigation of drug delivery through the nail plate. PhD Thesis, University of Basel (Sponsor TLT Medical, Switzerland). Imjak J., 2010. Roll compaction of pharmaceuticals, Postdoctoral fellow, University of Basel. Chansanroj K., 2011. Sucroseesters as novel controlled release agents for oral drug delivery matrix tablets, Postdoctoral fellow, University of Basel. Abdel-Hamid S., 2011. Instrumentation of tableting machines: High speed compaction investigation through simulation and radial die-wall monitoring. PhD Thesis, University of Basel (Sponsor Egyptian Ministry of Higher Education). Flicker F., 2011. Investigation of the variability of carbamazepine raw material. PhD Thesis, University of Basel (Sponsor: Senglet Stiftung, Basel). Saeed M., 2011. Implementation of near infrared spectroscopy to tablet production, Postdoctoral fellow, University of Basel (Sponsor: Novartis Pharma AG Stein).
10. Organisation of Symposia and Workshops
2008 “Modern solid dosage form process design and development using chemometric,
PAT, and simulation approaches” Workshop organized by G. Betz in the frame of FIP (Fédération internationale pharmaceutique) World Congress held in Basel.
2009 “The growing importance of Industrial Pharmacy” Symposium at University of
Basel, organized by G. Betz, K. Chansanroj, and I. Jeon.
2010 “Polymorphismus in Pharmaceuticals: Impact of ICH Guidelines” Symposium at
University of Basel, organized by A. Seelig, G. Betz, and D. Giron.
2010 “The growing importance of Industrial Pharmacy” Symposium at University of
Basel, organized by G. Betz, K. Chansanroj, and I. Jeon.
2011 Key Issues in Drug Discovery and Development: “Drug Design–From Molecule
to Final Formulation” organized by G. Betz and R. Alex, Roche.
11. Publications 11.1 Publications (peer-reviewed)
47. L. Martinez, G. Betz, R. Villalobos, L. Melgoza, P. Young. 2011. Correlation between compactibility values and excipient cluster size using an in-silico approach. Drug Dev. Ind. Pharm., submitted under review. 46. F. Flicker, V. Eberle, G. Betz. 2011. Recrystallization of Commercial Carbamazepine Samples – A Strategy to Control Dissolution Variability. Pharmaceutics, submitted under review. 45. N. Gentis, B. Vranic, G. Betz. 2011. Assessing compressibility and compactibility of powder formulations with near infrared spectroscopy. Pharm. Tech. Dev., submitted under review. 44. F. Alshihabi, Th. Vandamme, G. Betz. 2011. Investigation of the relationship between granule particle size and final tablet quality using fluid bed granulation process monitored by Focused beam reflectance measurement (FBRM) method. J. Drug Del. Sci. Tech., submitted under review. 43. J. Petrovic, K. Chansanroj, B. Meier, S. Ibric, G. Betz. 2011. Analysis of fluidized bed granulation process using conventional and novel modeling techniques. Eur. J. Pharm. Sci, Vol. 44, 227-234.
42. S. Abdel-Hamid, M. Koziolek, G. Betz. 2011. Effect of lubricant, binder, and drug loading on radial die-wall pressure. Drug Dev. Ind. Pharm., accepted in press. 41. F. Alshihabi, T. Vandamme, G. Betz. 2011. Focused beam reflectance method as an innovative (PAT) tool to monitor in-line granulation process in fluidized bed. Pharm. Tech. Dev., accepted in press. 40. N. Gentis and G. Betz. 2011. Compressibility of binary powder formulations: Investigation and evaluation with compaction equations. J. Pharm. Sci., accepted in press. 39. K. Chansanroj, J. Petrovic, S. Ibric, G. Betz. 2011. Drug release control and system understanding of sucrose esters matrix tablets by artificial neural networks. Eur. J. Pharm. Biopharm., Vol. 44, 321-331. 38. E. Hadzovic, G. Betz, S. Hadzidedic, S. Kocova El-Arini, H. Leuenberger. 2011. Investigation of compressibility and compactibility parameters of roller compacted theophylline and its binary mixtures. Int. J. Pharm., 416, 97-103. 37. F. Flicker and G. Betz. 2011. Effect of Crospovidone and Hydroxypropyl Cellulose on Carbamazepine in High-Dose Tablet Formulation. Drug Dev. Ind. Pharm., accepted in press. 36. S. Abdel-Hamid and G. Betz. 2011. Investigating the effect of punch geometry on high speed tableting through radial die-wall pressure monitoring. Pharm. Dev. Technol., accepted in press. 35. S. Abdel-Hamid, Firas Alshihabi, G. Betz. 2011. Investigating the effect of particle size and shape on high speed tableting through radial die-wall pressure monitoring. Int. J. Pharm., 413, 29-35. 34. S. Abdel-Hamid and G. Betz. 2011. Radial die-wall pressure as a reliable tool for studying the effect of powder water activity on high speed tableting. Int. J. Pharm., 411, 152-161. 33. S. Abdel-Hamid and G. Betz. 2011. A novel tool for the prediction of tablet sticking during high speed compaction. Pharm. Dev. Technol., accepted, in press. 32. F. Flicker, V. Eberle, G. Betz. 2011. Variability in commercial carbamazepine samples – Impact on drug release. Int. J. Pharm., 410, 99-106. 31. I. Jeon and G. Betz. 2011. Roll compaction as a dry granulation method for paracetamol. J. Drug Del. Sci. Tech., 21(3), 257-262. 30. I. Jeon, T. Gilli, G. Betz. 2011. Evaluation of roll compaction as a preparation method for hydroypropyl cellulose-based matrix tablets. J. Pharm. Bioallied Sci., Vol 3,
Issue 2, 213-220. 29. K. Bürki, I. Jeon, C. Arpagaus, G. Betz. 2011. New insights into respirable protein powder preparation using a nano spray dryer. Int. J. Pharm., 408, 248-256. 28. M. Saeed, L. Probst, G. Betz. 2011. Assessment of diffuse transmission and reflection modes in near-infrared quantification – part II: diffuse reflection information depth. J. Pharm. Sci., Vol. 100, No. 3, 1130-1141. 27. S. Abdel-Hamid and G. Betz. 2011. Study of radial die-wall pressure changes during pharmaceutical powder compaction. Drug Dev. Ind. Pharm., 37, 387-395. 26. I. Vejnovic, C. Huonder, G. Betz. 2010. Permeation studies of novel terbinafine formulations containing hydrophobins through human nails in vitro. Int. J. Pharm., 397, 67-76. 25. E. Hadzovic, G. Betz, S. Hadzidedic, S. Kocova El-Arini, H. Leuenberger. 2010. Roller compaction of different pseudopolymorphic forms of theophylline: effect on compressibility and tablet properties. Int. J. Pharm., 396, 53-62. 24. M. Pasic, G. Betz, S. Hadzidedic, S. Kocova El-Arini, H. Leuenberger. 2010. Investigation and development of robust process for direct pelletization of lansoprazole in fluidized bed rotary processor using experimental design. J. Drug Del. Sci. Tech., 20(5), 367-376. 23. V. Balzano, G. Betz, H. Leuenberger. 2010. Multiple unit pellet systems (MUPS) obtained by soft compaction of two polymorphic cellulose modifications as coated pellets: influence of the polymorphic modification in MUPS on disintegration time and drug release. Int. J. Biotech., Vol.11, Nos. 3/4, 182-202. 22. K. Chansanroj and G. Betz. 2010. Sucrose esters with various hydrophilic-lipophilic properties, novel controlled release agents for oral drug delivery matrix tablets prepared by direct compaction. Acta Biomaterialia 6, 3101-3109. 21. I. Jeon, Bikrom, A. Kumar, T.F. Vandamme, G. Betz. 2010. Dry granulation and tableting of St. John’s wort dry extract: effect of roll compaction variables, excipients, and tableting speed on granule and tablet properties, J. Drug Del. Sci. Tech., 20 (2) 111- 118. 20. B. Ivic, S. Ibric, G. Betz, Z. Djuric. 2010. Optimization of drug release from compressed multi unit particle systems (MUPS) using generalized regression neural network (GRNN). Archives of pharmacal research, Vol 33 (1), 103-113. 19. I. Vejnovic, L. Simmler, G. Betz. 2010. Investigation of different formulations for drug delivery through the nail plate. Int. J. Pharm., 386, 185-194.
18. S. Sehic, G. Betz, S. Hadzidedic, S. Kocova-El Arini, H. Leuenberger. 2010. Investigation of Intrinsic Dissolution Behaviour of Different Carbamazepine Samples. Int. J. Pharm., 386, 77-90. 17. I. Jeon, B. Maurya, T. Gilli, Th. F. Vandamme, G. Betz. 2009. How to minimize the limitations of roll compaction. Pharm. Tech. Europe, Vol. 21, Issue 12, 1-4. 16. B. Ivic, S. Ibric, G. Betz, Z. Djuric. 2009. Evaluation of diclofenac sodium release from matrix pellets compressed into MUPS tablets. Journal of Pharmaceutical Society Japan, Yakugaku Zasshi, Vol. 129, No. 11, 1375-84. 15. J. Petrovic, S. Ibric, G. Betz, J. Parojcic, Z. Duric. 2009. Application of dynamic neural networks in the modeling of drug release from polyethylene oxide matrix tablets. Eur. J. Pharm. Sci., 38 (2) 172-180. 14. M. Saeed, S. Saner, H. Keller, J. Oelichmann, G. Betz. 2009. Assessment of diffuse transmission mode in near-infrared quantification - Part I: The press effect on low-dose pharmaceutical tablets. J. Pharm. Sci., 98 (12) 4877-4886. 13. H. Leuenberger, M. Puchkov, E. Krausbauer, G. Betz. 2009. Manufacturing Pharmaceutical Granules: Is the Granulation Endpoint a Myth? Powder Technology 189, 141-148. 12. E. Krausbauer, M. Puchkov, G. Betz, H. Leuenberger. 2008. Rational estimation of the optimum amount of non-fibrous disintegrant applying percolation theory for binary fast disintegrating formulation. J. Pharm. Sci., 97(1)529-541. 11. G. Kimura, M. Puchkov, G. Betz, H. Leuenberger. 2007. Tablet formulation research for quality by design: Percolation theory and the role of maize starch as a disintegrant for a low water soluble drug. Pharm. Dev. Tech., 12(1)11-19. 10. G. Kimura, G. Betz, and H. Leuenberger. 2007. Influence of Loading Volume of Mefenamic Acid on Granules and Tablet Characteristics Using a Compaction Simulator. Pharm. Dev. Tech., 12(6)627-635. 9. K. Chansanroj, G. Betz, H. Leuenberger, A. Mitrevej, N. Sinchaipanid. 2007. Development of a multi-unit floating drug delivery system by hot melt coating technique with drug-lipid dispersion. J. Drug Del. Sci. Technol. 17(5)333-338. 8. K. Chansanroj, G. Betz, H. Leuenberger, A. Mitrevej, N. Sinchaipanid. 2007. Role of tempering process on accelerating a stable form of hydrogenated soybean oil used as hot melt coating agent. J. Drug Del. Sci. Technol., 17(5)347-352.
7. K. Chansanroj, P. Praserthdam, G. Betz, H. Leuenberger, A. Mitrevej, N. Sinchaipanid. 2006. Experimental design and optimization of the hydrogenation process of soybean oil. J. Drug Del. Sci. Tech., 16 (3) 229-234. 6. G. Betz, A. Aeppli, N. Menshutina, H. Leuenberger. 2005. In vivo comparison of various liposome formulations for cosmetic application. Int. J. Pharm. 296, 44-54. 5. G. Betz, P. Junker Bürgin, H. Leuenberger. 2004. Power Consumption Measurement and Temperature Recording during Granulation. Int. J. Pharm. 272, 137-149. 4. G. Betz, P. Junker Bürgin, H. Leuenberger. 2003. Batch and Continuous Processing in the Production of Pharmaceutical Granules. Pharm. Dev. Tech., Vol.8, Issue 3, 289-297. 3. G. Betz, P. Junker Bürgin, H. Leuenberger. 2003. Power Consumption Profile Analysis and Tensile Strength Measurements during Moist Agglomeration Process. Int. J. Pharm. 252, 11-25. 2. G. Betz, R. Imboden, G. Imanidis. 2001. Interaction of liposome formulations with human skin in vitro. Int. J. Pharm. 229, 117-129. 1. G. Betz, P. Nowbakht, R. Imboden, G. Imanidis. 2001. Heparin penetration into and permeation through human skin from aqueous and liposomal formulations in vitro. Int. J. Pharm. 228, 147-159. 11.2 Publications (non peer-reviewed)
G. Betz. 2006. The Industrial Pharmacy Lab: New Concepts in Powder and Process Technology. Chimia 1-2/2006, 50-53. H. Leuenberger, N. Menshutina, G. Betz, M. Puchkov. 2006. E-learning and Development of New Courses and Scientific Work in the Field of Pharmaceutical Technology. Chimia 1-2/2006, 80-82. G. Betz. 2005. Advancing formulation techniques: A research institute in Basel explains its latest approaches to industrial formulations. In: Inside Switzerland of PharmaTechnology, Winter 2005, 72-79. 11.3 Book chapters
H. Leuenberger, S. Kocova El-Arini, G. Betz. 2008. Pharmaceutical Powder Technology - Building the pyramid of knowledge and the challenge of FDA’s PAT initiative. In: Water In-soluble drug formulation. Ed. Rong Liu, 2nd edtition, Interpharm press, Denver, Colorado.
H. Leuenberger and G. Betz. 2008. Granulation Process Control – Production of Pharmaceutical Granules: The Classical Batch Concept and the Problem of Scale-up. In: Handbook of Powder Technology. Ed. Agba Salman, Volume 2. H. Leuenberger, G. Betz, D. Jones. 2006. Drugs and the Pharmaceutical Sciences 157, Scale-up in Granulation and Drying. In: Pharmaceutical Process Scale-up, Editor: M. Levin, 2nd edition, Marcel Dekker, Inc., 199-236. 12. Presentations given by G. Betz (selection)
Generics – same or different? (2011) 2nd Congress of pharmacy, Banja Luka, Bosnia & Hercegovina, 17.-20. November 2011. Disc intrinsic dissolution measurement to monitor polymorphism and morphology of carbamazepine (2010) SOTAX Congress Basel: A congress focused on Dissolution Testing Innovation for Pharmaceutical Laboratories, Basel, 22-23 September 2010. Liquid sterile dosage forms and biopharmaceuticals (2010) Future University, Cairo, Egypt, February 2010. The growing importance of Industrial Pharmacy (2009) BIOPHARM Symposium - Influence of Processing and Formulation Variables on Drug Release and Bioavailability, Belgrade, Serbia, October 2009. Scale-up of the tabletting process (2009) Strategies and trends in pharmaceutical development and production, Continuing Education Course of the Center of Pharmaceutical Sciences Basel-Zurich, 2009. Variability of primary material and its influence on intrinsic dissolution rate measurement, Solvias AG, Basel, Switzerland, 24. January 2008. Dimensional Analysis and Scale up of the tabletting process (2008), FIP preliminary workshop 68th FIP World Congress of Pharmacy and Pharmaceutical Sciences, August 31- September 4, 2008 Basel, Switzerland. New concepts in process technology and pharmaceutical drug formulation design (2007) The 3rd International Conference of Pharmaceutical and Drug Industries Division: Future Trends in Research and Development of Drugs, National Research Center, Cairo, Egypt, 6-8 March 2007. Non-invasive Drug Delivery (2007) 4th Moscow International Congress, Biotechnology: State of the art & prospects of development, Moscow, 12-16 March 2007.
Transdermal application of liposomes (2007) 4th Moscow International Congress, Biotechnology: State of the art & prospects of development, Moscow, 12-16 March 2007. In vivo comparison of various liposomal formulations for cosmetic application (2007) 7th International Cosmetic Symposium, Istanbul, Turkey, 20-23 June 2007. Industrial Pharmacy-Robust Pharmaceutical Formulation Design (2007) CIFARM, Riberao Preito, Brasil, 3-6 September 2007. Formulation School with Colorcon: “Functionality of Excipients and the Questions of Scale-Up of the Tableting Process” and “Excipient Selection” Budapest, Hungary, 26-27 November 2007. New Concepts in Powder and Process Technology (2006) Agglomerations- und Schüttguttechnik
Verfahrenstechnik und Chemieingenieurwesen GVC, Reinbek, Germany, 20. March 2006. New Concepts in Powder and Process Technology (2005) WHTS 3rd Annual Congress of International Drug Discovery Science and Technology, Theme: From Concepts to Market, Shanghai, China, 28. October - 3. November 2006. The impact of percolation theory and fractal dimension on formulation design (2005) Water-Insoluble Drug Delivery-Innovative Preformulation and Formulation Approaches for Improved Delivery, Philadelphia, PA, 18. -20. July 2005. Investigations of matrix systems from network-forming starch (2005) Pharmaceutical Sciences Fair, Nice, France, 12.-17. June 2005. New Concepts in Powder Technology and Solid Dosage Form Design (2005) 8th International Symposium on Agglomeration, Bangkok, Thailand, 16.03.-18.03.2005 We turn your active substance into a drug delivery system (2004) Casino Bern, Swiss Science Forum, NETS Special Award Ceremony, Bern. 11.10.2004. We turn your active substance into a drug delivery system (2004) Lausanne Palace, NETS Award Ceremony, Lausanne. 10.09.2004. Selected as the NETS Special Award 2004. The Industrial Pharmacy Lab (2004) Swiss House of Advanced Research (SHARE), Cambridge, MA, 14.06.2004. Selected as the most promising project by the audience in the frame of the NETS program. Application of Percolation Theory for the Development of Robust Formulations (2003) ECA Pharmaceutical Facilities – Solida Technology, Vienna, Austria, 23.10.2003.
In vivo comparison of various liposomal formulations for cosmetic application (2003) 5th Central European Symposium on Pharmaceutical Technology and Biotechnology, Ljubljana, Slovenia, September 2003. Research at the Institute of Pharmaceutical Technology, Pharmacenter University of Basel (2002) Swiss Innovation Week, Switzerland-China Scientific Workshop, New Swiss Technologies and Findings for China, Beijing and Shanghai, June 2002. New Trends in the Production of Pharmaceutical Granules: Batch vs. Continuous Processing (2001) AAPS Annual Meeting, Denver, Colorado, October 2001. The estimation of bioaccessibility of condensed dispersed systems in dermatological investigations (2001) Contribution to the lecture of Pharmacological speciality of Prof. Avramenko at Mendeleyev University of Chemical Technology of Russia (MUCTR), Moscow, May 2001. 13. Posters (selected since 2007)
Predicting the granule properties in fluid bed using FBRM as innovative method (2011) F. Alshihabi, Th. Vandamme, G. Betz. Pharmaceutical Sciences for the Future of Medicines, 3rd Pharm Sci Fair in Prague,Czech Republic, June 2011. FBRM as a PAT tool for in-line monitoring of particle growth kinetics in wet granulation processes (2011) F. Alshihabi, Th. Vandamme, G. Betz. International Granulation Workshop, Lausanne, June 2011. Simultaneous determination of two actives in powders and tablets using NIR spectroscopy (2011) B. Vranic, V. Frost, G. Betz. 15th International Conference on NIR spectroscopy in South Africa, May 2011. Permeation of caffeine loaded ethosomes and liposomes through the human nail plate (2010) S. Tuncay, I. Vejnovic, Ö. Özer, T. Güneri, G. Betz. 7th World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology in Valetta, Malta, March 2010. Effects of tabletting compaction variables and powder morphology on radial die wall pressures (2010) S. Abdel-Hamid, S. Mansour, G. Betz. 7th World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology in Valetta, Malta, March 2010. Investigation of near infrared diffuse transmission and reflection sampling span in pharmaceutical tablets (2010) M. Saeed, L. Probst, G. Betz. 7th World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology in Valetta, Malta, March 2010.
Compaction behavior of powder mixtures with focus on the tablet relative density (2010) N. Gentis, B. Vranic, G. Betz. 7th World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology in Valetta, Malta, March 2010. Optimization of powder compaction – a challenge for industrial manufacturing science (2010) N. Gentis and G. Betz, DIA meeting, Monaco, March 2010. PAT tools for in-line monitoring of particle growth and granule properties in wet granulation processes (2010) F. Alshihabi, T. Vandamme, G. Betz, 2nd International Conference on Drug Discovery and Therapy, February 1st- 5th, 2010, Dubai, UAE. Development and evaluation of different formulations for drug delivery through the nail plate (2009) I. Vejnovic, L. Simmler, G. Betz, Skin and Formulation 3rd Symposium, Versailles, France, 9.-10. März 2009. Sucrose esters – Controlled release regulators for direct compacted matrix (2009) K. Chansanroj and G. Betz, 4th International Conference: Research and Development in Drugs National Research Centre: Pharmaceutical and Drug Industries Division, 3-5 March 2009, Cairo Egypt. Development of Fast Disintegrating MUPS Tablets for Sustained Release of Paracetamol (2009) M. Yamashita and G. Betz, 4th International Conference: Research and Development in Drugs National Research Centre: Pharmaceutical and Drug Industries Division, 3-5 March 2009, Cairo Egypt. Correlating and modeling tablet physical properties to radial die wall pressure (2009) S. Abdel-Hamid and G. Betz, Pharmaceutical Science Fair, Nice, France, June 2009. Roll compaction of paracetamol and process optimization by central composite design (2009) I. Jeon, G. Betz, Pharmaceutical Science Fair, Nice, France, June 2009. Disc intrinsic dissolution measurement to monitor polymorphism and morphology of carbamazepine (2009) F. Flicker, S. Sehic, G. Betz, 69th FIP World Congress Istanbul, 02.-10. September 2009. Permeability studies through the human nail plate in vitro (2009) I. Vejnovic, L. Simmler, G. Betz, 69th FIP World Congress Istanbul, 02.-10. September 2009. Effect of compaction pressure and speed on radial die wall pressure (2009) S. Abdel- Hamid and G. Betz, 2nd Swiss Science Day, Bern, Switzerland, September 2009. Coated tablets consisting of a super disintegrant core and its effect on drug release (2009) E. Darronqui, M. Schillinger, G. Betz, H. Leuenberger, CIFARP, Ribeirão Preto, Brazil, September 2009.
Mechanical properties evaluation of pharmaceutical compacts by in silico and experimental process (2009) L. Martinez, G. Betz, R. Villalobos, Symposium of Pharmaceutical Technology, University of Mexico, Facultad de Estudios Superiores Cuautitlan, 18-19 November 2009. Prediction of Drug Content in Intact Tablets by Near-Infrared Spectroscopy (2009) B. Vranic, V. Frost, G. Betz. BIOPHARM Symposium 2009 - Influence of Processing and Formulation Variables on Drug Release and Bioavailability, Belgrade, Serbia, 22-23 October 2009. Development and evaluation of different formulations for drug delivery through the nail plate, I. Vejnovic, L. Simmler, G. Betz. 68th FIP World congress of pharmacy and pharmaceutical sciences, September 2008, Basel, Switzerland. Development and evaluation of different formulations for drug delivery through the nail plate, I. Vejnovic, L. Simmler, G. Betz. Biovalley life sciences week, October 2008, Basel, Switzerland. Compressibilty and Compactability of Different Batches of Modified Cellulose (2008) F. Müller, G. Betz, H. Leuenberger. 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 7-10 April 2008. Modified Celluloses as Excipients in Fast Dissolving Tablets (2008) F. Müller, M. von Moos, G. Betz, H. Leuenberger. 68th FIP World congress of pharmacy and pharmaceutical sciences, September 2008, Basel, Switzerland. Design and Study of Theophylline Fast Disintegrating Multiple Unit Pellets Systems (MUPS) (2008) Ch. Asawahame, K. Chansanroj, G. Betz, H. Leuenberger. First Swiss Pharma Science Day, October 2008, University of Bern, Bern Switzerland. Sucrose esters – Controlled release regulators for direct compacted matrix tablets (2008) K. Chansanroj, S. Bösch, G. Betz. 68th FIP World congress of pharmacy and pharmaceutical sciences, September 2008, Basel, Switzerland. Influence of polymorphic transformation of a triglyceride base on drug release from hot melt coated pellets (2008) K. Chansanroj and G. Betz. The 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 7- 10 April 2008. Influence of Roll pressure during roll compaction on the granule- and tablet properties produced with paracetamol/microcrystalline cellulose-mixture (2008) I. Jeon and G. Betz. 7th Central European Symposium on Pharmaceutical Technology and Biodelivery Systems, Ljublijana, Slovenia, September 2008.
Influence of Roll pressure during roll compaction on the granule- and tablet properties produced with paracetamol/microcrystalline cellulose-mixture. I. Jeon and G. Betz. First Swiss Pharma Science Day October 2008, University of Bern, Bern, Switzerland. Quantitative near infrared (NIR) spectroscopy for low-dose tablet formulations. S. Saner, M. Saeed, G. Betz (2007) 5th International Symposium on Solid Oral Dosage Forms, Stockholm, Sweden, 7-9 May 2007. Soft compaction of MCC 102 and UICEL pellets into MUPS. V. Balzano, G. Betz, H. Leuenberger (2007) Pharmaceutical Sciences World Congress, Amsterdam, The Netherlands, 22-25 April 2007. Role of tempering process on accelerating a stable form of hydrogenated soybean oil used as hot melt coating agent. K. Chansanroj, G. Betz, H. Leuenberger, A. Mitreveja, N. Sinchaipanida (2007) Pharmaceutical Sciences World Congress, Amsterdam, The Netherlands, 22-25 April 2007. Investigations on ASA tablets degradation behavior in presence of UICEL, MCC, and Cornstarch. M. Rumman, G. Betz, H. Leuenberger (2007) Pharmaceutical Sciences World Congress, Amsterdam, The Netherlands, 22-25 April 2007. Formulation of tertiary systems to improve dissolution characteristics of curcumin. G. Borini, G. Betz, H. Leuenberger, L.A. Pedro de Freitas (2007) Pharmaceutical Sciences World Congress, Amsterdam, The Netherlands, 22-25 April 2007. Influence of enteric coating polymer on gastric resistance and dissolution of lansoprazole pellets. M. Pasic, G. Betz, S. Hadzidedic, S. Kocova El-Arini, H. Leuenberger (2007) The 3rd International Conference of Pharmaceutical and Drug Industries Division: Future Trends in Research and Development of Drugs, National Research Center, Cairo, Egypt, 6-8 March 2007. Carbamazepine Polymorphs and Dihydrate Comparative Study. S. Sehic, G. Betz, S. Hadzidedic, S. Kocova El-Arini, H. Leuenberger (2007) The 3rd International Conference of Pharmaceutical and Drug Industries Division: Future Trends in Research and Development of Drugs, National Research Center, Cairo, Egypt, 6-8 March 2007. Effect of Roll Compaction on Polymorphic Forms and Compressibility of Theophylline. E. Brka, G. Betz, S. Hadzidedic, S. Kocova El-Arini, H. Leuenberger (2007) The 3rd International Conference of Pharmaceutical and Drug Industries Division: Future Trends in Research and Development of Drugs, National Research Center, Cairo, Egypt, 6-8 March 2007. Near Infrared (NIR) Spectroscopy for Process Analytical Technology: Investigating a Robust Calibration Model. M. Saeed, M. Ulmschneider, H. Keller, G. Betz (2007) The 3rd International Conference of Pharmaceutical and Drug Industries Division: Future
Trends in Research and Development of Drugs, National Research Center, Cairo, Egypt, 6-8 March 2007. Investigation of ethylcellulose coated fine drug pellets and multiple unit pellet systems (MUPS) using confocal laser scanning microscopy (CLSM). H. Yamaguchi, H. Myojo, H. Leuenberger, G. Betz (2007) The 1st Conference on innovation in Drug Delivery: From Biomaterials to Devices, Hotel Royal Continental, Naples, Italy, 30 September-3 October 2007. Fully hydrogenated soybean oil: a lipid carrier for a multi-unit floating drug delivery system. K. Chansanroj, G. Betz, H. Leuenberger, A. Mitrevej, N. Sinchaipanid (2007) The 1st Asian Biomaterials Congress, Tsukuba, Japan, 6-8 December 2007. Accelerated Stability Testing and Shelf-life Prediction. M. Pasic, G. Betz, S. Hadzidedic, S. Kocova El-Arini, H. Leuenberger (2007) The 4th Congress of Pharmacy of Macedonia with International Participation. Macedonia, Ohrid, 27-30 September 2007. Effect of Roll Compaction on Disintegration Time and Dissolution Rate of Theophylline, E. Hadzovic, G. Betz, S. Hadžidedić, S. Kocova El-Arini, H. Leuenberger, Tablet Tech Seminar, Brussel, Belgium, 25.-26. October 2007. Effect of Roll Compaction on Polymorphic Forms and Compressibility of Theophylline, E. Hadzovic, G. Betz, S. Hadžidedić, S. Kocova El-Arini, H. Leuenberger, Tablet Tech Seminar, Brussel, Belgium, 25.-26. October 2007. Effect of Roll Compaction on Disintegration Time and Dissolution Rate of Theophylline, E. Hadzovic, G. Betz, S. Hadžidedić, S. Kocova El-Arini, H. Leuenberger, Congress of Pharmacy Macedonia with International Participation, Ohrid , Macedonia, 26.-30. September 2007.
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