Uktech.ac.in

DETAILED SYLLABUS
MSc Pharma Chemistry
Semester-I
QUANTITATIVE ANALYTICAL METHODS
General: Computation of analytical results, significant figures, concept of error, precision and
accuracy, standard deviation, rejection of doubtful values with special reference to volumetric and
gravimetric analysis, calibration of analytical equipments.
Fundamental of volumetric analysis: Methods of expressing concentrations, primary and secondary
standards.
Unit-II
Neutralization reactions: Theory of indicators and neutralization indicators.
Oxidation-reduction titration: Principle of oxidation reduction filtrations, redox indicators & their
use in pharmaceutical analysis.
Unit-III
Precipitation titration: Theory of precipitation titrations and use of adsorption indicators.
Gravimetric analysis: Method of gravimetric analysis
Complexometric titrations: Complexometric methods using EDTA, principle of complexometric
titrations, chelating agents, indicators, titrations with disodium edetate.
Nonaqueous titrations:General discussion and principle of titrations in non-equeous media, aprotic,
protophilic, protogenic and amphiprotic solvents. Titrations with perchloric acid, potassium methoxide and tetrabutyl ammonium hydroxide.
Ionic equations, numerical problems based on above topics BOOK RECOMMENDED
A. H. Becket and J. B. Stenlake, Practical Pharmaceutical Chemistry, Part I, 4th ed., CBS Publishers & Distributors, New Delhi, 1997.
G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney Vogel’s Text Book of Quantitative Chemical Analysis 5th ed., ELBS, U.K., 1989.
A. Keneth & A. Connors, A Text Book of Pharmaceutical Analysis, 3rd ed., WileyInterscience Singapore, 1982.
Semester-I
BIOCHEMISTRY
Enzyme, enzyme kinetics, enzyme action, biological oxidation & reduction.
Energy metabolism, bioenergetics, Introduction to Intermidiary metabolism and carbohydrate
metabolism.
Unit-III
Protein & nucleic acid metabolism, lipid, water and mineral metabolism.
Biosynthesis of protein, transmission & expression of genetic information, DNA genetic role, Structurereplicationof m-RNA, transcription, gene protein relationship and control of gene.
Immunoglobulins, structure classification, and their biological role. Vitamins, skeleton structure and theirbiological role.
BOOKS RECOMMENDED
Robert K. Murray, Daryl K. Granner, Peter A. Mayes, Victor W. Rodwell, Harper’s Biochemistry, 25th ed. McGraw Hill health Professions Division, New York, USA, 1998.
A.V.S.S. Rama Rao, Text Book of Biochemistry, 6th ed., L. K. & S. Publishers, Melson David L. Lehninger Principles of Biochemistry, 3rd ed. Macmillan worth Publishers, Stryer Lubert, Berg Jeremy M., Tymoczko Johan L, Biochemistry, 5th ed. W. H. Freeman & M. C. Pant, Essentials of Biochemistry, 8th ed., Kedar nath Ram Nath & Co. Publishers, E. David Metzler, Carol M. Metzler, David J. Sauke, Biochemistry the chemical reactions of living cells, 2nd ed., Har court/Academic Press, New York.
Semester-I
ADVANCE ORGANIC CHEMISTRY
Optical isomerism, configuration, Cahn-Ingold-Prelog rule for designation of configuration.
Stereochemistry of carbon compounds with no chiral atom, Biphenyls, Allenes, Alkylidenecycloalkanes,
spirans and Geometrical isomerism.
Unit-II
Stereoisomerism of rings, stability of rings, ease of ring formation, Actual shape of six membered rings &
its relation to properties & reactivity and Conformational analysis of Butane.
Unit-III
Carbocation, Carbanions, free radicals, formation and stability. Mechanism of reaction & methods of
determining them. Mechanism involving aliphatic nucleophilic and electrophilic substitution reactions.
Unit-IV
Mechanisms involving Aromatic eletrophilic and aromatic nucleophilic substitution reactions, free radical
reactions. Addition to carbon-carbon multiple bonds & elimination reactions.
Unit-V
Study of Name Reactions such as: Fries Rearrangement Beckmann rearrangement, Hofmannrearrangement, Curtius reaction, Schmidt Reaction, Claisen’s Condensation, Wittig Reaction, Oppenaueroxidation, Meerwein Pondroff Valery Reduction, Birch Reduction, Clemmensen reduction, Reimer-Tiemann Reaction, Wolf Kishner’s Reduction, , Pinacol-Pinacolone Rearrangement and AldolCondensation, BOOKS RECOMMENDED:
E.L. Eliel Stereochemistry of carbon compounds, Tata McGra Hill Publishing Company NewDelhi 1975.
Jerry March, Advance organic Chemistry 4th ed. A Wiley-Interscience Publication, 1999.
Semester-I
BASIC PHARMACOLOGY
History of development of Pharmacology, introduction & general principles of route of drug
administration, pharmacokinitics (absorption, distribution, metabolism & excreation)a pharmacodynamics
(general mechanism of drug action).
Unit-II
Elementry introduction to adverse drug reactions & drug interactions, Drug allergy.
Unit-III
Toxicity
General concepts of toxicity, Acute, subacute & chronic toxicity tests, teratogenicity & carcinogenicity,itrogenic diseases, LD50, ED50, tolerance, habituation & addiction.
Bio-assays: General principles, general methods, biological variations & animal ethics. Bioassays of
insulin, heparin, d-tubocurarin, digitalis, acetylcholine, adrenaline, histamine.
Unit-V
General principles of screening of drugs, general screening methods, clinical trial. Screening methods forevaluation of anti-inflammatory, analgesics, antipyretics & antiulcer, anticonvulsants, hepatoprotective,antidiabetic, diuretic and drugs acting on CNS.
BOOKS RECOMMENDED
1. Goodman & Gillman, The Pharmacological Basis of Therapeutics 9th ed., McGraw Hill
2. Katzung G. Bertram, Basic and Clinical Pharmacology, 8th ed., McGraw Hill Companies, New
3. Rang H.P., Dale M.M., Ritter J.M., Pharmacology, 4th ed., Churchill livingstone, N. Y., 1999.
4. R.S. Satoshkar, Pharmacology and Pharmacotherapeutics, vol. I & II: 16th ed., Mumbai Popular
5. Munson L. Paul, Principles of Pharmacology, Chapman & Hill, N. Y. 1995.
6. S. K. Kulkarni & P.C. Dandiya, Introduction to Pharmacology, 5th ed. Vallabh Prakasha, 1998.
7. Laurence & Bennett, Clinical Pharmacology, 8th ed., Churchill Livingstone, N. Y. 1997.
8. S. D. Seth, Text Book of Pharmacology, 2nd ed. Churchill Livingstone Pvt. Ltd., New Dlhi.
9. F.S.K. Barar, Essential of Pharmacotherapeutics, 3rd ed. S. Chand and Company Ltd., New Delhi,
10. K.D. Tripathi, Essentials of Medical Pharmacology, 9th ed., Jaypee Brothers New Delhi, 1995.
Semester-I
Practical
MPC-114P
A. Synthesis of organic compounds involving 2 or more steps.
B. Detection and identification of organic compound mixture.
Semester-II
MODERN ANALYTICAL TECHNIQUES -1
Chromatography: Principles Instrumentation, Application of adsorption, partition, paper, thin layer,
HPTLC, HPLC, Gel Electophorsis GLC Gas and, Ionexchange Chromatography.
Unit-II
Colorimetry: theroy, methods of colour measurements and instrumentation.
Unit-III
Optical rotation, its significance, instrumentation.
Optical rotatory dispersion-terminology, plain curve, rotatory dispersion & circular dichroism and
octane rule.
Unit-IV
Atomic absorption and flame emission spectroscopy, theory, instrumentation, atomic absorption
spectrophotometers and structure determinations.
Unit-V
UV & infrared spectroscopy: Principle, techniques, instrumentation & application including
interpretation of data.
BOOKS RECOMMENDED
Robert M. Silverstein, Francis X. Webster, Spectrometric identification of organic compounds, 6th ed. John Wiley and Sons-Inc 1998.
Comin N. Banwell, Elian M. McCash, Fundamentals of molecular spectroscopy 4the ed. Tata McGraw -Hill Publishing Company Limited New Delhi, 1995.
A.H. Becket and J.B. Stenlake, Practical Pharmaceutical Chemistry, part- II, 4th ed., CBS Publishers & Distributors, New Delhi, 1997.
W. Kemp, Organic Spectroscopy, 1st ed. ELBS/Macmillan, London, 1975.
Semester-II
PHYSICAL PHARMACY & BIOPHARMACEUTICS
Preformulation studies: Factors affecting dissolution, diffusion – pH, pka, KO/W, particle size, solubility
etc. Methods to increase solubility of poorly soluble drugs, drug release mechanisms. Factors
affecting/necessating preformulation of Drug.
Micromeritics: Introduction, pharmaceutical importance, particle size distribution, surface area and
particle volume, derived properties of powder, flow properties of powder, angle of repose, factors
affecting flow of powders. Different methods of particle size determination.
Surface and interfacial tension: Measurement of surface and interfacial tension, spreading coefficient,
general classification of surfactants, hydrophilic- lipophilic balance. Solubilization, factors affecting
solubilization, micelle formation, factors affecting micelle formation, determination of critical micelle
Concentration, detergency and wetting agents. Contact angle, flocculating agents, de-flocculating agents,
foaming and antifoaming agents. Pharmaceutical applications of surfactants.
UNIT-III
Colloids: Pharmaceutical application of colloids, brief introduction to properties of colloids.
Coarse dispersions: Physical stability of suspension and emulsions, types of suspension, controlled
flocculation-floculated suspension, types of emulsion, theories of emulsification, emulsifying agents-mechanism of action, factors to improve physical stability of emulsions.
Rheology: Fundamentals of rheology, types of flow, thixotropy, thixotropy in formulations, rheology of
disperse system, Pharmaceutical applications of rheology. Types of viscometers.
Chemical kinetics: Influence of temperature, light, oxygen acid base catalyst and methods to prevent
drug degradation. Prediction of stability, accelerated stability studies.
Disintegration: Disintegration, Disintegration time, factors affecting disintegration
Dissolution: Dissolution, dissolution models, factors affecting dissolution rate, co-relation of dissolution
with bioavailability.
BOOKS RECOMMENDED
Remington’s Pharmaceutical Sciences-Gennaro A.R., ed., 19th Edition, Mack Publishing co., Martin's Physical Pharmacy and Pharmaceutical Sciences, 5th edition by Patrick C. V. S. Subrahmanyam, Atext book of physical pharmaceutics, 2 nd ed, Vallabh Leon Lachman, Herbert A, Lieberman, Joseph L. Kanig; The Theory & Practice of Semester-II
CHEMISTRY OF NATURAL PRODUCTS
Heterocyclic Compounds: Five membered heterocycles: Furan, Thiophene, pyrole, thiazole, pyrazole,
oxazole, imidazole, Six membered hydrocycles: Pyridine, pyrimidine.
Benzfused heterocycles: Quinoline, isoquinoline and indole.
Unit-II
Carbohydrate: Introduction, mutarotation, ring structure of glucose, configuration of monosaccharides,
structure elucidation of disaccharides, sucrose and maltose. Polysaccharides, starch. Glycosides: general
structural elucidation of glycoside including cardiac glycosides.
Unit-III
Alkaloids: General introduction, distribution in plants, isolation & purification. General methods of
structure determination. Structural elucidation of atropine, quinine and Nicotine. Structural features of
morphine and Caffiene.
Unit-IV
Terpenoids: General introduction, isolation, purification and structure elucidation of citral, menthol,
camphor.
Unit-V
Steroids: General introduction and structure elucidation of sterols with special reference to cholesterol.
BOOKS RECOMMENDED
1. I.L. Finar, Organic chemistry, Vol. II, 1st Indian ed., Pearson Education Pte Ltd Indian Branch,
2. O.P. Agarwal, Chemistry of Natural Products, Vol. I & II, 7th ed., Goel Publishing House,
Semester-II
BIOSTATISTICS AND COMPUTERS
Unit I
Introduction and scope of Biostatistics
Presentation of data: classification of data, Methods of collection of data (primary and secondary),
frequency distribution, graphical representation of data by histogram, frequency polygon, frequency curve and cumulative frequency curve.
Central tendency and measures of dispersion, mean, median, mode and their properties, partition
value, standard deviation and coefficient of variation, simple correlation coefficient and regression coefficient, regression lines, tests of significance: t-test, z-test, chi-square tests, F-test, heterogeneity and independence of attributes.
Unit II
Testing of hypothesis
Types of errors, power of test, test of significance based on normal distribution T-test for mean of
population, difference of means of two normal population, chi-square test of goodness of fit, independent test, test of variance of normal population F-test for variance ration, correlation and regression, latest square methods and its application, significance of coefficient of correlation, rank correlation curve fitting and sign test.
Unit III
Computer fundamentals
Sample model of computer and its working, input-output devices, computer languages and their hierarchy
(low level and high level), Introduction to microcomputers, concept of operating system, computer networking, Introduction of software (MS-Word, MS-Excel & Power point etc.)
Unit IV
Introduction of C++ Programming
Difference between C and C++, concept of OOP'S, basic data types and operators, sample programs,
conditional statements(IF-ELSE ,NESTED IF),concept of looping(for, while and do-while),Introduction to subscripted variables(single and double), classes and objects, function & function overloading, constructor and destructor, pointers.
UNIT V
Internet and its working, Uniform resource locator (URL), World wide web, HTTP, Internet explorer.
Role of computers in pharmaceutical sciences.
Books Recommended:
1. Information technology-D.P.Curtin, Tata McGraw Hill,New Delhi.
2. Guide to Medical Informatics, The Internet & Telemedicine-E Coiera, Amold Publishers, USA.
3. Biostatistics-Arora & Malhan, Himalaya Publishing House, Bombay.
4. Statistical Methods in Biology-Baidy, Cambridge University press.
5. P. K. Sinha, B.P.B Publication New Delhi.
Semester-II
H-121P LABORATORY I
H-123P LABORATORY II
Laboratory II shall constitute of the following: A. Natural Products-Isolation and identification of compounds.
B. Phytochemical test for Carbohydrate, Alkaloids, Steroids, Terpenoids, Amino acids, Semester-II
MODERN ANALYTICAL TECHNIQUES -1I
Molecular Emission Spectroscopy: Principle, molecule exhibiting florescence, Factors interfering with
florescence intensity and Application, Raman Spectroscopy-Principle, Instrumentation and Application
Unit-II
Mass Spectroscopy: Principle, techniques, instrumentation, fragmentation pattern & structural
elucidation of compounds. GC-MS and LC-MS Principle and Application.
Unit-III
Proton Magnetic Resonanace, Principle, techniques, instrumentation, 1HNMR signals, chemical shift,
spin-spin coupling, shielding desheilding effect, diamagnetic anisotropy, geminal coupling, AMX, ABX,
ABC system, shift reagents & interpretation of spectra. 13C-NMR, introduction and interpretation of data.
Unit-IV
Application of spectroscopic techniques to structural elucidation, introduction aids to spectral
intepretation exercises.
Unit-V
Microbiology assays, Principles of microbiological assays, assays of vitamins & antibiotics.
BOOKS RECOMMENDED
Robert M. Silverstein, Francis X. Webster, Spectrometric identification of organiccompounds, 6th ed. John Wiley and Sons-Inc 1998.
Comin N. Banwell, Elian M. McCash, Fundamentals of molecular spectroscopy 4the ed. TataMcGraw -Hill Publishing Company Limited New Delhi, 1995.
A.H. Becket and J.B. Stenlake, Practical Pharmaceutical Chemistry, part- II, 4th ed., CBS Publishers & Distributors, New Delhi, 1997.
W. Kemp, Organic Spectroscopy, 1st ed. ELBS/Macmillan, London, 1975.
Semester-111
DRUG DELIVERY SYSTEM & BIOPHARMACEUTICS
Types, advantages, disadvantages & formulation and evaluation/quality control of oral dosage formsincluding: Liquid dosage forms like solution, syrups, suspension & emulsion.
Solid dosage forms like tablets, capsules etc.
Semisolid dosage like ointment, cream, gels.
Parenteral drug delivery system: Preparation, Evaluation and quality control. A brief introduction to
new approach such as liposomes, neosomes, nanoparticles, Resealed erythrocytes as novel parenteral drug
delivery.
Unit-III
Controlled release drug delivery system.
Advantages, drug properties relevant of controlled release formulation.
Oral dosage form: diffusion system, dissolution system, osmotic pump ion exchange resin & prodrug.
Parenteral dosage form: Intramuscular injection & implants.
Unit-IV
Drug absorption: factors affecting drug absorption including physicochemical, biological and
pharmaceutical. Passive and active diffusion.
Unit-V
Drug disposition: Distribution in blood, plasma protein binding, cellular distribution, drug excertion,
biotransformation of drugs.
Bioavailability: Concept of bioavailability & comparative bioavailability, methods of estimation of
bioavailability, bioequivalence studies.
BOOKS RECOMMENDED
Remington’s Pharmaceutical Sciences-Gennaro A.R., ed., 19th Edition, Mack Publishing co., Leon Lachman, Herbert A, Lieberman, Joseph L. Kanig; The Theory & Practice of B. M. Mithal, A text book of pharmaceutical formulation, 6th edition, Vallabh prakashan Fundamentals of Clinical Pharmacokinetics-Wagner, J.C., Drug Intelligence Publication, M.
Clinical Pharmacokinetics-Rowland, M, & Tozer, N., 2nd edition, Lea & Febiger, Pharmacokinetics-Gibaldi M. & Perrier, D., 2nd ed., Marcel Dekker, New York, 1982.
Biopharmaceutcs and Pharmacokinetics- Notrari, R.E., 2nd ed., marcel Dekker, New York, Biopharmaceutcs and Pharmacokinetics: Bramhankar & Jaiswal.
Semester-III
Medical Chemistry I (Chemotherapeutic Agents)
Chemical Classifications, SAR Studies, Mode of actions and Therapeutic uses.
Unit-I
Beta lactam antibiotics: Penicillins, Cephalosprins including their semi-synthetic products. Monobactams.
Unit-II
Tetracyclines, Semi-synthetic tetracyclines, Gentamycins, Neomycins, Kanamycins, Fluoroquinoolines
type of antibacterials.
Unit-III
Sulfonamides, Antileprotics, Antimycobacterials, Antifungals.
Unit-IV
Antiprotozoal includes – Antimalarials, Antiamoebics, Antihelminths.
Unit-V
Anticancer, Antivirals and Synthesis of following drugs involving not more than three steps.
5- Fluorouracil, 6 -Mercaptopurine, Amoxycillin, Ampicilln, Benzathine, Benzidiazole, Busulfan,
Cefrozil, Cepirone, Chloroquine, Ciprofloxacin, Clotrimazole, Cyclophosphamide, Dapsone,
Deoxycycline, Diloxamide., Ethionamide, Fucytocine, Hydroxy urea, Idoxuridine, Isoniazid,
Ketoconazole, Loracarbef, Mafenide Acetate, Melphalan, Metronidazole, Pamaquine, Penicillins G,
Piperazine Citrate, Proguanil, Pyrimethamine, Sulfadioxime, Sulfasalazine, Thiabendazole, Thiotepa,
Trimethoprin.
BOOKS RECOMMENDED
William O. Foye, Principles of Medicinal Chemistry, 3rd ed., Varghese Publishing House, Jaime N. Delgado & William A. Remers, Wilson and Gisvold’s, Text Book of Organic Medicinal and Pharmaceutical Chemistry, 9th ed. J.B. Lippincott Company, Philadelphia, Manfred E. Wolff, Burger’s Medicinal Chemistry & Drug Discovery, 5th ed., Wiley H. Singh and V.K. Kapoor, Medicinal and Pharmaceutical Chemistry, 1st ed., Vallabh Ashutosh Kar, Medicinal Chemistry, New Age International (P) Limited, New Delhi, 1993.
Semester – III
MPC – 134
Drug Design
 Specific and non-specific drug action Drug receptors Basic concept and classification of receptors Forces involved in drug receptors- interactions Receptor agonism and antagonism Concept of Spare receptors Simple kinetics of drug- receptor interaction Receptor theories: Clark’s occupancy theory, Ariens-Stephenson modification, Induced fit and Topographical study of the following receptors includes only preferred conformations,pharmacophores and modes of bindings/interactions  Adrenergic Cholinergic Opioid receptors H-1 & H-2 receptors Diazepine Serotonin Unit-III
 Concept of isosterism and bioiososterism and their applications in drug design Antimetabolite approach to drug design Analog drug design Prodrugs and drug latentiation  Carrier-linked prodrugs Bioprecursors Role of functional groups in prodrug design  General pathways of drug metabolism and simple kinetics of drug metabolism Pharmacokinetic oriented drug design  Stereochemical aspects of drug action  Setereoselectivity of optical isomers Role of planarity in drug action  Stereoselectivity of conformational isomers  Types of QSAR models Classification of parameters utilized in QSAR studies Statistical concept of QSAR Hansch model of QSAR De Novo model of QSAR Hammett and Taft model of QSAR equations Applications of QSAR in drug design  Basics of combinatorial chemistry Rational approach to drug design Basic strategies of drug discovery Role of molecular docking/modeling in drug design, computer assisted drug design Books Recommended:
William O. Foye, Principles of Medicinal Chemistry, 3rd ed., Varghese Publishing House,Mumbai, 1989.
Jaime N. Delgado & William A. Remers, Wilson and Gisvold’s, Text Book of OrganicMedicinal and Pharmaceutical Chemistry, 9th ed. J.B. Lippincott Company, Philadelphia,1991.
Manfred E. Wolff, Burger’s medicinal Chemistry and Drug Discovery, Vol. I to V, 5thed., A Wiley-Interscience publication John Wiley & Sons, Inc. (New York), 1995.
Kadam & Mahadik, Bothara, Principles of Medicinal Chemistry vol. I & II, 4th ed. NiraliPrakash Pune, 1997 LABORATORY-I
MPC-131P ANALYSIS OF PHARMACEUTICALS
1. The laboratory shall constitute analysis of dosage form, typical pharmacopial assays, including disintegration time, dissolution rate, friability etc.
LABORATORY- II
MPC-132P SYNTHETIC MEDICINAL CHEMISTRY
1. Synthesis of Compounds using 3-4 steps,.
2. Structure confirmation by spectroscopic methods3. Interpretation of UV, IR, 1HNMR and Mass Spectroscopy of compounds.
4.
Semester-IV
Medical Chemistry II (Pharmacodynemic Agents)
Chemical Classifications, SAR Studies, Mode of actions and Therapeutic uses of the following
classes of drugs.
Unit-I
Drugs acting on CVS – Antianginals, Antihypertensives, Antilipidemics, Antiarrhythmics, Diuretics.
Unit-II
Analgesics – Narcotic and NSAIDs, Antipyretics, Uricosurics (Antigouts).
Unit-III
Drug acting on CNS – Hypnotic Sedative only, Barbiturates and halogenated drugs, Antiepileptics,
General anaesthetics, Antiparkinsonian drugs
Unit-IV
Psychotherapeuticals – Antipsychotics, Anxiolytic drugs, Antidepressants and Antidiabetics.
Unit-V
H - 1 – R blockers (Anti-histaminics), H – 2 – R blockers (Anti-ulcers), Carbohydrate based drugs,
Oligonucleotides and Synthesis of following drug involving not more than three steps:
Acetazolamide, Amantidine HCl, Amyl nitrate, Amoexpine, Buspropion, Captopril, Carbamazepine,
Cetrizine, Chlorocyclizine, Chloropheniramine, Chloropromazine, Chloropropamide, Cimetidine,
Clofibrate, Clonidine HCl, Desipiramine, Diazepam, Diltiazem HCl, Diphenyhydramine, Disopyramide,
Enalapril maleate, Enthimate, Ethacrynic acid, Ethosuximide, Felodipine, Fentanyl citrate, Fluvastatin,
Fluoxetine, Furasemide, Gemfibrozil, Glipizide, Guanethidin monosulphate, Hydrothiazide, Imipramine,
Ibuprofen, Isosorbide dinitrate, Labetolol, Loratidine, Lorazepam, Lovastatin, Meperidine, Methadone,
Methyldopatate HCl, Nalorphine, Naloxone, Nitrazepam, Oxycodone, Phenoformin, Phenytoin,
Polythiazide, Procainamide, Promazine, Propoxyphene napsylate, Propranolol, Pyrilamine maleate,
Ranitidine, Salsalate, Sotalol, Sufindac, Tolbutamide, Triamterene, Triazolam, Trimeprazine,
Thioridazine, Tripelennamine maleate, Verampril.
BOOKS RECOMMENDED
William O. Foye, Principles of Medicinal Chemistry, 3rd ed., Varghese Publishing House, Jaime N. Delgado & William A. Remers, Wilson and Gisvold’s, Text Book of Organic Medicinal and Pharmaceutical Chemistry, 9th ed. J.B. Lippincott Company, Philadelphia, Manfred E. Wolff, Burger’s Medicinal Chemistry & Drug Discovery, 5th ed., Wiley H. Singh and V.K. Kapoor, Medicinal and Pharmaceutical Chemistry, 1st ed., Vallabh Ashutosh Kar, Medicinal Chemistry, New Age International (P) Limited, New Delhi, 1993.
Semester-IV

Source: http://uktech.ac.in/sites/default/files/MSc_Pharm_Chemistry.pdf