Microsoft word - sedative and hypnotic withdrawal new_02-18-04.doc
Sedative and Hypnotic Withdrawal Worksheet Instrument: Modified CIWA-A
Patient: The trigger point for this protocol is 6. Symptoms & Intoxication Signs: Nystagmus
Give only one score for each block. Withdrawal Signs: Hallucinations
DBP > 100 Sitting/Standing Orthostasis
Sedative and Hypnotic Withdrawal Worksheet Instrument: Modified CIWA-A
Instructions:
1) Assessment and vital signs should be done on admission, then Q 2 hours
until stable, then Q 4 hours for 24 hours. Then every 8 hours for 24 hours. This schedule may have to be altered according to patient condition and physicians order. This work sheet should also be completed before giving routine detoxification medications to ensure patient is not over medicated.
2) If any signs of intoxication is noted, withhold scheduled detoxification
medication until you confer with the physician.
3) For vital signs with lying and standing measurements, give only one score. E.g. 102/110 score = 2. 4) Circle any abnormal measurements then total scores by referring to the rate
5) Orthostasis, when pulse increases more then 10 BPM or BP decreases more
then 10 mm HG when patient position changes from sitting to standing.
6) PRN detoxification medication should only be given if the patient meets a
score of 6 or greater or otherwise specified by physician.
7) Evidence of vomiting must be witnessed and documented to receive a score
1.) Dosage adjustment may be necessary according to clinical
2.) The physician should write day 2-6 medication orders.
3.) For Xanax and Halcion dependence give reported doses during
first 24 hours, until assessed by MD unless patient shows signs of intoxication. Consultation to an addiction psychiatrist is strongly advised.
4.) Skip dose if there are signs or symptoms of intoxication.
5.) Nystagmus: Rapid rhythmic repetitious involuntary (unwilled) eye
movements. Nystagmus can be horizontal, vertical or rotary.
6.) Ataxia: Wobbliness. Ataxia is incoordination and unsteadiness due
to the brain’s failure to regulate the body’s posture and regulate the strength and direction of limb movements. Ataxia is usually a consequence of disease in the brain, specifically in the cerebellum which lies beneath the back part of the cerebrum.
7.) Rhinorrhea: Medical term for a runny nose. From the Greek words
"rhinos" meaning "of the nose" and "rhoia" meaning "a flowing."
Sedative and Hypnotic Withdrawal Worksheet Instrument: Modified CIWA-A Recommended Detoxification Schedule: The physician will choose Librium or Ativan and carry one through the entire protocol.
Day 1: Give Librium 50 mg or Ativan 2.0 mg po q 4 hours prn total withdrawal signs and symptoms >= 6. Call MD if higher doses are required. Day 2: Give the 24 hours requirement (determined in Day 1) in TID dosing, plus
Librium 25 mg or Ativan 1.0 mg po q 4 hours. PRN withdrawal >= 6 for 4 days or as ordered by MD.
Day 3: Give approximately 75% of Day 1 total requirement in TID dosing. Day 4: Give approximately 50% of day 1 total in TID dosing. Day 5: Give approximately 25% of Day, 1 total in HS dosing. Day 6: Discontinue or give test dose in QD format.
Opioid Withdrawal Worksheet Instrument: Modified CIWA-D
The trigger point for this protocol is 7.
Signs and Symptoms: Intoxication Signs: Withdrawal Signs: Opioid Withdrawal Worksheet Instrument: Modified CIWA-D
1. Dosage adjustment may be necessary according to clinical response. 2. After one (1) day, MD may write routine medication orders.
3. Skip a dose if there are signs or symptoms of intoxication.
Intoxication < 3 mm / Withdrawal > 5 mm Intoxication If signs or symptoms present (+) * If (+), then PRN or schedule dose of medication skipped. Withdrawal 1) For vital signs with sitting/standing measurement, give only one score.
E.g. heart rate = sitting 102 / standing 110 score = 2
2) Circle abnormal measurements then total scores by referring to rating column. E.g. Temp 102 = 3 Orthostasis + = 2 Total score = 5 3) PRN detoxification medication should only be given if the patient meets a score of 7 or greater or otherwise specified by the physician. Orthostasis: Pulse increase greater then 10 BPM or blood pressure decreases greater than 10 mm HG when standing. Signature: Opioid Withdrawal Worksheet Instrument: Modified CIWA-D
Recommended Opioid Detoxification Schedule: The physician will choose methadone or clonidine and carry one through the entire protocol. Never use 2 detoxification protocols at the same time. Hold one substance constant and withdraw from the other. Day 1: Choice #1:
Methadone: give methadone 10 mg po q4h prn total withdrawal
signs and symptoms >=7. Call MD if higher doses are needed.
Give Clonidine 0.10 mg. q4h prn total withdrawal signs and symptoms >=7. Call MD if higher doses are needed.
Day 2: Choice #1:
Methadone: Give the 24 hour requirement (as determined in Day
Give Clonidine 0.10 mg po q4h prn total withdrawal signs and symptoms >=7. Call MD if higher does are needed.
Day 3: Choice #1:
Methadone Decrease the dose by 5 mg/day or 20% (whichever is less) of the previous day’s dose, starting with the am dose.
Give Clonidine 0.10 mg po q4h prn total withdrawal signs and symptoms >=7. Call MD if higher does are needed.
Day 4: Choice #1:
Methadone: Decrease the dose by 5 mg/day or 20% (whichever is less) of the previous day’s dose, starting with the am dose.
Clonidine: If WD signs and symptoms are < 7 then start tapering Clonidine by 0.1 mg/d until off
Day 5: Choice #1:
Methadone: Decrease the dose by 5 mg/day or 20% (whichever is less) of the previous day’s dose, starting with the am dose.
Clonidine: If WD signs and symptoms are < 7 then start tapering Clonidine by 0.1 mg/d until off
Day 6: Choice #1:
Clonidine: If WD signs and symptoms are < 7 then start tapering Clonidine by 0.1 mg/d until off.
Yamanashi Med. J. 17 (3), 69~ 74, 2002 Original Article Effects of Sildenafil (ViagraTM) on the Cyclic AMP Hydrolyzing Phosphodiesterase Activity in the Canine Heart Assessed Using a Modified Enzymatic Fluorometric Assay TechniqueAtsushi SUGIYAMA, Yoshiki SAEGUSA, Akira TAKAHARA Departments of Pharmacology and 1)Neurosurgery, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan Abstra